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Old 01-15-2016
Habiba88's Avatar
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Default Acute Intermittent porphyria/ urine coporphobilinogen

How's it that coporphobilinogen increased in AIP?
where does it come from?

I read other resources and they mentioned that uroporphyrinogen appears in urine
but FA mentioned that coporphobiligogen appears in urine

either way, neither of these make sense to me
any good explanation?
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Old 01-15-2016
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Quote:
Originally Posted by Habiba88 View Post
How's it that coporphobilinogen increased in AIP?
where does it come from?

I read other resources and they mentioned that uroporphyrinogen appears in urine
but FA mentioned that coporphobiligogen appears in urine

either way, neither of these make sense to me
any good explanation?
in acute intermittent porphyria, the substrate porphobilinogen will accumulate in urine. it spontaneously polymerizes to coporphobilinogen in urine --> giving urine port-wine color
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Habiba88 (01-18-2016), Usmle16Forall (09-19-2016)



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