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Old 03-21-2012
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Drug Phenytoin and lidocaine mechanism of action

is the mechanism of action same?
does phenytoin bind and stabilize inactivate channel or
does phenytoin lead to inactivation?
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Old 03-21-2012
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Both are class 1b antiarrhythmic

Penytoin works by promoting sodium efflux from neurons, thereby stabilizing threshold against hyperexcitability.

Lidocaine stabilizes the neuronal membrane by inhibiting the ionic fluxes required for the initiation and conduction of impulses.
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Old 03-21-2012
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Quote:
Originally Posted by bunny View Post
Both are class 1b antiarrhythmic

Penytoin works by promoting sodium efflux from neurons, thereby stabilizing threshold against hyperexcitability.

Lidocaine stabilizes the neuronal membrane by inhibiting the ionic fluxes required for the initiation and conduction of impulses.
Thanks, how about TCA cardiotox.? also same mechanism?
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Cardiotoxic effects primarily result from blockade of inactivated fast sodium channels in a use-dependent manner (blockade is higher at faster heart rates)
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