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Acantholysis, antibodies against desmogleins 1 and 3

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3K views 8 replies 6 participants last post by  hasanzahid 
#1 ·
An immunofluorescence study was performed in a patient with a well known dermatology disorder (See image). This disorder is related to acantholysis, antibodies against desmogleins 1 and 3, bullae formation after soft skin traction, and a positive Asboe-Hansen sign.

According to the image and the description above given. Which one of the below options best correlates with this disease?

  1. antibodies against epidermal basement membrane
  2. pruritic papules and vesicles
  3. Hyperplasia of stratum spinosum
  4. antiepithelial cell antibodies
  5. subepidermal blisters
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#4 ·
Answer is b ... This is pemphigus vulgaris , an important diagnostic tool by IF for the desmoglein antibodies.
It is intra epidermal not sub epidermal bullae and itis not against basement membrane but rather against desmosomes . The only thing left is itching and pruritis choice ! However one should put in mind that it is rarely pruritic!
 
#6 ·
Nop... This is 100% of my creation. I made it up from FA, some info here in the forum and my notes from UW. But the Q is not from UW, not even similar (Unless that by accident and without intention, it might resemble one, but this would be pure coincidence).

Happy-2
 
#7 ·
And the answer is Antiepithelial cell Antibodies. It is pemphigus vulgaris,but antibodies against epidermal basement membrane and subepidermal blisters arepart of the description of bullous pemphigoid, not pemphigus vulagris. :D:D:D
 
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#8 ·
pemphigus vulgaris, occurs WITHIN the epidermis, so it's not the basement membrane, nor the pruritic lesion, it's not sub-epidermal bullae , it's not hyperplasia of the spinosum, the most accurate answer for this is the antiepithelial antibodies.
the bullae arise within the epidermis due to acantholysis.
 
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