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Old 03-22-2012
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Liver Aspirin and Varicella!

A 3 year old Caucasian girl is brought to the physician by her mother, who reports that 5 days ago the girl developed a low grade fever, malaise, headache , cough, coryza and soar throat and a pruritic rash that started on the head an trunk and spread to the remainder of the body. Physical examinations reveals diffuse skin lesions in varying stages with macules, papules, vesicles and pustules present. Varicella is diagnosed. Before the girl is sent home, the mother is advised to give the child aspirin as an antipyretic. Four days later the girl is brought to the ER is a comatose state. The mother says that her daughter had been vomiting for the past two days and was eating poorly. Examination reveals hepatomegaly but no icterus.

Total bilirubin: 2.1 mg/dL
Direct bilirubin: 0.3 mg/dL
Alkaline phosphatase: 120 U/L
Aspartate aminotransferase: 358
Alanine aminotransferase: 410
Amonia (plasma): 94 umol/L
Glucose level: 62 mg / dL
Prothrombin time: 18 sec
PTT: 44 sec

Injury of which cellular organelle is most likely in this patient ?

A: Rough Endoplasmic Reticulm
B: Proxisome
C: Smooth Endoplasmic Reticulum
D: Lysosomes
E: Mitochondrias
F: Ribosomes
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Old 03-22-2012
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Default Rey's syndrome

E. Mitochondria

- Aspirin is usually given to treat viral illness, for this case..Varicella...
- But...DO NOT give aspirin to kids because it will lead to Rey's syndrome...damage to mitochondria
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Gastrointestinal-Tract-, Pathology-, Step-1-Questions

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