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Old 03-23-2012
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Default Atrophy in conn syndrom

Why is there atrophy of zona glomerulosa in Conn syndrome??
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Old 03-23-2012
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Conn syndrome occurs due to Aldosterone producing adenoma usually resulting in increased synthesis of mineralocorticoid by cells of zona glomerulosa. As therfore microscopically we find lipid laden cells resembling to cells of zona fasciculata,mature cortical cells showing some amount of nuclear and cellular pleomorphism,spironolactone bodies in patients treated with spironolactone previously. As aldosterone provides no influence in ACTH secretion so i think there is no atrophy at all of zona glomerulosa cells and opposite adrenal gland........but atrophy do occurs in case cushing syndrome as cause of hyperaldosteronism where cortisol decrease ACTH level thereby opposite adrenal gland becomes atrophied.
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Old 03-23-2012
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Quote:
Originally Posted by Master shifu View Post
Conn syndrome occurs due to Aldosterone producing adenoma usually resulting in increased synthesis of mineralocorticoid by cells of zona glomerulosa. As therfore microscopically we find lipid laden cells resembling to cells of zona fasciculata,mature cortical cells showing some amount of nuclear and cellular pleomorphism,spironolactone bodies in patients treated with spironolactone previously. As aldosterone provides no influence in ACTH secretion so i think there is no atrophy at all of zona glomerulosa cells and opposite adrenal gland........but atrophy do occurs in case cushing syndrome as cause of hyperaldosteronism where cortisol decrease ACTH level thereby opposite adrenal gland becomes atrophied.
yea thats what i thought until i listened to gojan (Neoplasia2)..
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