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Old 03-24-2012
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Default Reiterís syndrome

anyone know the cause of Reiterís syndrome
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Old 03-24-2012
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Chlamydia?
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Old 03-24-2012
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It's an autoimmune disorder that develops secondary to cross reactivity.
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Infections that can lead to the complication of Reiter's syndrome include a common sexually transmitted disease called chlamydia. This is the most common cause of Reiter's syndrome. A less common cause of Reiter's syndrome is food poisoning due to Salmonella, Shigella, Yersinia or Campylobacter infection. Why some people develop Reiter's syndrome in reaction to these infections and other people don't is not known, but having a certain genetic factor called HLA-B27 increases a person's chance of developing Reiter's syndrome.
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Microorganisms are believed to mimic self-peptides and to activate a self-immune response. Similarity between microorganisms and a novel gene that encodes a surface protein of activated natural killer (NK) cells has been reported. This evidence supports the hypothesis; however, the role of NK cells in Reiter syndrome has not been defined.

CD8 T cells are believed to play a role in Reiter syndrome because individuals with human immunodeficiency virus (HIV) infection have presented with Reiter syndrome, particularly individuals with significant CD4 suppression who are in advanced stages of infection. The simultaneous occurrence of Reiter syndrome in children and their parents suggests that similar etiologic factors are involved. Genetic carriage of human leukocyte antigen (HLA)-B27 in Reiter syndrome has been studied and is present in 67-92% of pediatric cases, although the rate varies with the frequency of the gene in the population at risk.

Although the role of HLA-B27 in disease pathogenesis remains unknown, mechanisms of interplay between the microorganism and the gene may be present. HLA-B27 may affect immune mechanisms other than classic antigen presentation, although the mechanism by which HLA-B27 confers susceptibility remains unknown. Indeed, Reiter syndrome does not develop in all family members who have diarrhea and carry HLA-B27; conversely, Reiter syndrome may develop in a family without carriage of HLA-B27 antigen, suggesting involvement by other unknown factors in Reiter syndrome pathogenesis. Disease penetrance of less than 50% in studies of monozygotic twins has been found. The risk of an individual with HLA-B27 actually developing Reiter syndrome is less than 1%.
http://emedicine.medscape.com/articl...overview#a0104
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