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Old 03-29-2012
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DNA Lymphoma oncogene association!

A patient presents with cervical lymphadenopathy. Biopsy demonstrates a nodular lymphoma with follicle formation. This lesion would most likely be associated with which of the following?

A) bcr-c-abl
B) bcl-2 activation
C) c-myc activation
D) t(8, 14)
E) t(9, 22)

**Try to explain all the options**
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Old 03-29-2012
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Bcl-2. overexpression, inhibition of apoptosis
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Originally Posted by DocSikorski View Post
Bcl-2. overexpression, inhibition of apoptosis
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intense disulfiram acrobatics %)
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Yep... B - follicular lymphoma

A -> This is CML, right? BCR and ABL?
C -> c-myc?? -> Argh. I can't remember... Where is this found again?
D -> burkitt's
E -> philadelphia chr; CML
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Originally Posted by d_wiqed View Post
Yep... B - follicular lymphoma

A -> This is CML, right? BCR and ABL?
C -> c-myc?? -> Argh. I can't remember... Where is this found again?
D -> burkitt's
E -> philadelphia chr; CML
both c-myc and t(8;14) are in Burkitts, (also starry sky)
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Old 03-29-2012
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The correct answer is B. Nodular lymphomas of all types are derived from the B-cell line. The translocation t(14, 18), with bcl-2 activation, is associated with these lymphomas.

An abl-bcr hybrid (bcr-c-abl; choice A) and t(9, 22) translocation (choice E) are associated with chronic myeloid leukemia (CML).

c-myc activation (choice C) and t(8, 14) (choice D) are associated with Burkitt lymphoma.
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