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Dose needed to achieve steady state?

3K views 6 replies 3 participants last post by  Casandra 
#1 ·
Pharmacokinetic characteristics of propranolol include Vd - 300 L/70 kg, CI = 700 mL/min, oral bioavailability f = 0.25. What is the dose needed to achieve a plasma level equivalent to a steady-state level of 20 g/L?

A. 4mg
B. 8mg
C. 12 mg
D. 24 mg
E. 48 mg

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#5 ·
g-> mg?

I think there's a typo and in the stem it should say

"a plasma level equivalent to a steady-state level of 20 mg/L" NOT "20 g/L".
That's the only explanation that makes sense to me.

Assuming that it is 20mg/L and using loading dose formula I would calculate this as follows:

(Vd x Cp) / f = 300L x 20 mg/L / 0.25 = 24000 mg = 24 g -> the answer D

Please correct me if I'm wrong.
 
#6 ·
I think there's a typo and in the stem it should say

"a plasma level equivalent to a steady-state level of 20 mg/L" NOT "20 g/L".
That's the only explanation that makes sense to me.

Assuming that it is 20mg/L and using loading dose formula I would calculate this as follows:

(Vd x Cp) / f = 300L x 20 mg/L / 0.25 = 24000 mg = 24 g -> the answer D

Please correct me if I'm wrong.
Yes considering its typo its correct but that is 6 typos in one unit of kaplan pharm 😡

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