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Old 04-01-2012
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Question How did this patient get the infection??

A patient with an 8-month history of neurological decline dies after a severe bout of aspiration pneumonia. Autopsy of her brain reveals extensive loss of granule cells in the cerebellum and other changes most obvious in the cerebellar cortex. Fine vacuoles give the brain a spongiform appearance. No senile plaques are evident. The patient could have acquired this progressive disease through which of the following means?

a. Sexual intercourse
b. A blood transfusion
c. Consumption of raw fish
d. An upper respiratory infection
e. Growth hormone treatment
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e- growth hormone treatment

they have spongiform brain disease or CJD, which is caused by prions... the prions may be acquired by giving GH from a patient with these prions after he died to a healthy one
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Old 04-01-2012
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Good one.

Very very good one.
Yes its growth hormone (i only got it by exclusion + GH is the only thing derived from the brain...)
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Quote:
Originally Posted by DocSikorski View Post
Good one.

Very very good one.
Yes its growth hormone (i only got it by exclusion + GH is the only thing derived from the brain...)

i studied it this morning, dr sattar in pathoma said it literally like that
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read the question and thought prions
read the options and didnt see the classical prion-related associations
so i started crying

so you can get prion infection from GH therapy? wow ok, cool.
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Quote:
Originally Posted by Dr.NickRiviera View Post
so you can get prion infection from GH therapy? wow ok, cool.
im sure u know that u can get it by eating infected cows brains, or people who are know for Cannibalism which is "eating human" including their brains.... well, GH is extracted from peoples' [pituitary] brain's after they die... so u'll a get prion infection that way u wont forget it

its a true story btw, thats what really happens
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The correct answer is e; Growth hormone treatment.

The most likely cause of spongiform encephalopathy in this middle-aged woman is Creutzfeldt-Jakob disease. This is classified as a prion disease and can be transmitted via infected nervous system tissue, including dura mater grafts, and occasionally via growth hormone preparations acquired from cadaver pituitary glands. A similar disease (kuru) occurs in Fore Islanders of New Guinea and is presumed to spread through the ritual handling or eating of human brain tissue
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