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Old 04-29-2010
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Neuro Which Neurotransmitter Distrubance is responsible?

A 45-year-old male is brought to the emergency department by his family, who has noted him to be behaving bizarrely. There is a family history of early death. He is unable to control pronounced choreiform movements of his upper extremities and trunk. Which of the following is the most likely neurotransmitter disturbance?

A- Depletion of acetylcholine
B- Depletion of dopamine
C- Depletion of gabaaminobutyric acid
D- Excessive production of acetylcholine
E- Excessive production of dopamine
F- Excessive production of gabaaminobutyric acid
G- Excessive production of norepinephrine
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Old 04-29-2010
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Default ?

Huntington's disease, deceased levels of GABA and Ach. So A or C.
Choice C. No inhibition by GABA
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Old 04-29-2010
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Info Huntington's Disease and GABA

Eventually, HD knocks out many neurons throughout the basal ganglia, but it apparently starts with the inhibitory GABA neurons projecting to the Gpe from the putamen. GABA, gamma-aminobutyric acid, is the primary inhibitory neurotransmitter in the brain. When these neurons are functioning normally, they cause decreased inhibition of motion through a long pathway in the basal ganglia. Knocking out the GABA neurons in the putamen will result in excess motor signals from the GPi.

Answer is C of course
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