does drug like 5-FU cause megaloblastic anemia - USMLE Forums
USMLE Forums Logo
USMLE Forums         Your Reliable USMLE Online Community     Members     Posts
Home
USMLE Articles
USMLE News
USMLE Polls
USMLE Books
USMLE Apps
Go Back   USMLE Forums > USMLE Step 1 Forum

USMLE Step 1 Forum USMLE Step 1 Discussion Forum: Let's talk about anything related to USMLE Step 1 exam


Reply
 
Thread Tools Search this Thread Display Modes
  #1  
Old 03-04-2016
USMLE Forums Scout
 
Steps History: Not yet
Posts: 10
Threads: 8
Thanked 0 Times in 0 Posts
Reputation: 10
Help does drug like 5-FU cause megaloblastic anemia

Hi there, in pathoma it said 5-FU causes macrocytic anemia without megaloblastic cells. But 5-FU causes lacking folate right? then why no megaloblastic cells?
very confused, please help!
Reply With Quote Quick reply to this message



  #2  
Old 03-06-2016
Little Turtle's Avatar
USMLE Forums Newbie
 
Steps History: ---
Posts: 3
Threads: 0
Thanked 0 Times in 0 Posts
Reputation: 10
Default

Quote:
Originally Posted by Emilyworkhard View Post
Hi there, in pathoma it said 5-FU causes macrocytic anemia without megaloblastic cells. But 5-FU causes lacking folate right? then why no megaloblastic cells?
very confused, please help!

I would go with yes since anything that blocks pyrimidine or purine synthesis including methotrexate or 6-mercaptopurine will cause megaloblastic anemia
Reply With Quote Quick reply to this message
  #3  
Old 03-06-2016
USMLE Forums Scout
 
Steps History: Step 1 Only
Posts: 49
Threads: 7
Thanked 5 Times in 4 Posts
Reputation: 15
Default

Quote:
Originally Posted by Emilyworkhard View Post
Hi there, in pathoma it said 5-FU causes macrocytic anemia without megaloblastic cells. But 5-FU causes lacking folate right? then why no megaloblastic cells?
very confused, please help!
5-FU does not really affect folate levels, 5-FU blocks the thymidilate synthetase enzyme.
If you want a drug blocking folate you'd go with methotrexate.
Reply With Quote Quick reply to this message



Reply

Quick Reply
Message:
Options

Register Now

In order to be able to post messages on the USMLE Forums forums, you must first register.
Please enter your desired user name, your email address and other required details in the form below.
User Name:
Password
Please enter a password for your user account. Note that passwords are case-sensitive.
Password:
Confirm Password:
Email Address
Please enter a valid email address for yourself.
Email Address:
Medical School
Choose "---" if you don't want to tell. AMG for US & Canadian medical schools. IMG for all other medical schools.
USMLE Steps History
What steps finished! Example: 1+CK+CS+3 = Passed Step 1, Step 2 CK, Step 2 CS, and Step 3.

Choose "---" if you don't want to tell.

Favorite USMLE Books
What USMLE books you really think are useful. Leave blank if you don't want to tell.
Location
Where you live. Leave blank if you don't want to tell.

Log-in

Human Verification

In order to verify that you are a human and not a spam bot, please enter the answer into the following box below based on the instructions contained in the graphic.



Thread Tools Search this Thread
Search this Thread:

Advanced Search
Display Modes


Similar Threads
Thread Thread Starter Forum Replies Last Post
What is the mechanism of forming hypersegmented neutrophils in megaloblastic anemia? HaipengWang USMLE Step 1 Forum 2 12-08-2014 11:58 AM
why 5-FU zidovudine hydroxyurea causes non-megaloblastic anemia? FionU USMLE Step 1 Forum 1 07-02-2014 12:54 PM
Megaloblastic Anemia Question drsrb USMLE Step 2 CK Forum 11 07-31-2013 09:14 AM
Question of the day #4 (Megaloblastic anemia in a child) Haisook USMLE Step 1 Forum 8 04-07-2011 12:07 PM
AntiTB drug cause sideroblastic anemia FSUSTC USMLE Step 2 CK Forum 7 03-09-2010 12:29 PM

RSS Feed
Find Us on Facebook
vBulletin Security provided by vBSecurity v2.2.2 (Pro) - vBulletin Mods & Addons Copyright © 2017 DragonByte Technologies Ltd.

USMLE® & other trade marks belong to their respective owners, read full disclaimer
USMLE Forums created under Creative Commons 3.0 License. (2009-2014)