Gamma Inteferon is not virus specific! - USMLE Forums
USMLE Forums Logo
USMLE Forums         Your Reliable USMLE Online Community     Members     Posts
Home
USMLE Articles
USMLE News
USMLE Polls
USMLE Books
USMLE Apps
Go Back   USMLE Forums > USMLE Step 1 Forum

USMLE Step 1 Forum USMLE Step 1 Discussion Forum: Let's talk about anything related to USMLE Step 1 exam


Reply
 
Thread Tools Search this Thread Display Modes
  #1  
Old 04-08-2012
USMLE Forums Addict
 
Steps History: Not yet
Posts: 183
Threads: 79
Thanked 17 Times in 13 Posts
Reputation: 27
Immunology Gamma Inteferon is not virus specific!

UW says that its not virus specific.

Isn't virus protein endogenously processed (in rER via TAP channel) then loaded on MHC I which is presented to Th1 cell, therefore activating CD8 and macrophage specifically directed to that protein on MHC I?
i thought CD8 has TCR which has variable region just like antibody..
I understand that IFN alpha and beta is not virus specific but IFN gamma should be or?
Reply With Quote Quick reply to this message



  #2  
Old 04-08-2012
USMLE Forums Addict
 
Steps History: Step 1 Only
Posts: 127
Threads: 3
Thanked 113 Times in 62 Posts
Reputation: 123
Default

MHC I doesn't bind to Th1 cells, it binds to CD8 cells.

Th cells express CD4 and they bind to MHC II.

IFN-g is secreted by CD4 cells when they bind to MHC II; this process promotes differentiation of Th1 cells and recruitment of macrophages.

Th1 can then recruit CD8 cells which will be targeted to kill a particular cell, but not a particular virus. And of course, the macrophages don't know what they're killing.
Reply With Quote Quick reply to this message
  #3  
Old 04-08-2012
Hope2Pass's Avatar
USMLE Forums Master
 
Steps History: 1+CK+CS+3
Posts: 1,684
Threads: 213
Thanked 1,595 Times in 660 Posts
Reputation: 1605
Default

Here's what I thought -

Macrophages express MHC II when they cannot kill off a virus and become Antigen Presenting Cells and present the Antigen to the CD 4 T helper cells which then secretes the cytokines to activate more macrophages (IFN gamma) and IL-2 (to cause T cell differentiation)
Reply With Quote Quick reply to this message
 
  #4  
Old 04-08-2012
USMLE Forums Addict
 
Steps History: Not yet
Posts: 183
Threads: 79
Thanked 17 Times in 13 Posts
Reputation: 27
Default

oh gt confused
Reply With Quote Quick reply to this message
  #5  
Old 04-08-2012
USMLE Forums Addict
 
Steps History: Step 1 Only
Posts: 127
Threads: 3
Thanked 113 Times in 62 Posts
Reputation: 123
Default

Th cells also stimulate macrophages to be more effective somehow. Not sure how that happens.
Reply With Quote Quick reply to this message
  #6  
Old 04-08-2012
Kabutar111's Avatar
USMLE Forums Guru
 
Steps History: Not yet
Posts: 414
Threads: 30
Thanked 87 Times in 70 Posts
Reputation: 97
Send a message via Skype™ to Kabutar111
Default chemokine exchange

Quote:
Originally Posted by shan564 View Post
Th cells also stimulate macrophages to be more effective somehow. Not sure how that happens.
increases Ag presentation n differentiation ,which inc Th cell activity even further
__________________
There is no shortcut to SUCCESS ,and there is no excuse for FALIURE - by Kabutar111
To view links or images in signatures your post count must be 10 or greater. You currently have 0 posts.
Reply With Quote Quick reply to this message



Reply

Tags
Immunology-

Quick Reply
Message:
Options

Register Now

In order to be able to post messages on the USMLE Forums forums, you must first register.
Please enter your desired user name, your email address and other required details in the form below.
User Name:
Password
Please enter a password for your user account. Note that passwords are case-sensitive.
Password:
Confirm Password:
Email Address
Please enter a valid email address for yourself.
Email Address:
Medical School
Choose "---" if you don't want to tell. AMG for US & Canadian medical schools. IMG for all other medical schools.
USMLE Steps History
What steps finished! Example: 1+CK+CS+3 = Passed Step 1, Step 2 CK, Step 2 CS, and Step 3.

Choose "---" if you don't want to tell.

Favorite USMLE Books
What USMLE books you really think are useful. Leave blank if you don't want to tell.
Location
Where you live. Leave blank if you don't want to tell.

Log-in

Human Verification

In order to verify that you are a human and not a spam bot, please enter the answer into the following box below based on the instructions contained in the graphic.



Thread Tools Search this Thread
Search this Thread:

Advanced Search
Display Modes


Similar Threads
Thread Thread Starter Forum Replies Last Post
during digeorges syndrome gamma glogulin level...??? dr.digant USMLE Step 1 Forum 1 07-21-2011 02:29 AM
Program specific LORs b.abid IMG Residency Match Forum 3 02-18-2011 03:36 PM
PPAR-gamma aktorque USMLE Step 1 Forum 4 02-02-2011 10:56 AM
program specific resume? Neutrophil IMG Residency Match Forum 6 01-03-2011 11:46 AM
Sequence-specific cleavage doctorF USMLE Step 1 Forum 3 04-03-2010 09:55 AM

RSS Feed
Find Us on Facebook
vBulletin Security provided by vBSecurity v2.2.2 (Pro) - vBulletin Mods & Addons Copyright © 2017 DragonByte Technologies Ltd.

USMLE® & other trade marks belong to their respective owners, read full disclaimer
USMLE Forums created under Creative Commons 3.0 License. (2009-2014)