Glanzmann's Thrombocytopenia vs Bernard Soulier vs Aspirin - USMLE Forums
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Old 04-09-2012
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Blood Glanzmann's Thrombocytopenia vs Bernard Soulier vs Aspirin

Quick question - for all of these diseases listed; Glanzmann's Thrombocytopenia (defect in GP IIA/IIIB), Bernard Soulier disease (defect in GP IB), and Aspirin toxicity (decreased thromboxane A2); the main defect is in Platelet AGGREGATION.

Do all of them show the same signs? For example, do all of them have mild thrombocytopenia with ENLARGED PLATELETS ?
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Old 04-09-2012
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As far as i remember only Bernard Soulier disease had thrombocytopenia and large platelets-adhesion is deffective

Glanzmann's-platelet aggregation deffect

And aspirin-inhibitor of txa2 mediated vasoconstriction + inhibitor of platelet aggregation



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Glanzmann's thrombasthenia is a deficiency of Glycoprotein IIb/IIIa (GpIIb/IIIa)on platelets. This receptor is supposed to be activated when the platelet is stimulated by ADP, epinephrine, collagen or thrombin. The activated receptor has the ability to bind fibrinogen, which is required for fibrinogen-dependent platelet-platelet interaction (aggregation.)

Bernard Soulier disease causes a deficiency of glycoprotein Ib (GpIb), the receptor for vWF.

Both would have an abnormal bleeding time, while other lab results would be normal. I think it is reasonable to assume that the signs and symptoms would be the same.
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