Effects of B-blockers and Nitrates on EDV - USMLE Forums
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Old 04-11-2012
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Drug Effects of B-blockers and Nitrates on EDV

FA pg.281 says Nitrates decrease EDV and B-blockers increase it, how so?

Shouldnt Nitrates increase EDV? (via vasodilation of veins and therefore more blood to the heart, increased preload).
And i cant really see a connection to how B-blockers affect EDV.
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Nitrates cause veno dilation-meaning less return of blood to heart- EDV decreases.
Beta blockers slow down the heart rate-more time for diastolic filling-increase in EDV.
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Nitrates cause vasodilation of the veins (venodilation), therefore causing "pooling" of the blood in the veins, therefore decreasing the blood going back to the heart, therefore decreasing EDV and preload.

Can't remember how b-blockers affect EDV
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Old 04-11-2012
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B-blockers decrease HR n contractility>> decreased Stroke volume >> increased EDV ..

Nitrates >> effective venodilation(pooling of blood in venous system) more than arteriolar dilation>>decreased Venous return n increased contractility >> decreased EDv..

I just figured it out this
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Old 04-11-2012
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ahh pooling of blood, that makes sense
thanks guys
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