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Old 04-15-2012
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Drug Fibrates and cholesterol stones

Anyone know the mechanism for this??

I read on some other forum that fibrates decrease Bile Acid secretion thus resulting in supersaturated cholesterol stones.

Don't really understand the reasoning behind this.
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Old 04-16-2012
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Fibrates inhibit an enzyme 7-alpha something (sorry cnt really remember the name)

That enzyme normally, breaks down nonbile acid soluble cholesterol to Bile salt soluble cholesterol.

therefore, fibrates inhibit this enzyme and causes excess of insoluble cholesterol in gall bladder and cause super saturation causing cholesterol stone!

This is 1 important concept i learn from UW.


correct me if am wrong! :sorry::sorry::sorry::sorry::sorry:
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Old 04-17-2012
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"Fibrates by upregulating scavenger receptors increase liver delipidation of cholesterol from mature HDLs. Hepatic cholesterol can be used for many functions buts any excess is exported into the bile using upregulated ATP binding cassette transporters ABCG5 and ABCG8 which are found at the hepatobiliary interface. Fibrates through an effect on nuclear transcription factors are also involved with regulation of bile acid synthesis. It is conceivable that by changing the bile acid/cholesterol ratio may set up a trend towards lithogenic bile."

I copied this from: http://www.lipid.org/newcommunity/bl...cholelithiasis

It sounds a lot like the hypothesis that you gave, but I hope that it helps anyway.
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Old 04-17-2012
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Quote:
Originally Posted by aj23 View Post
Fibrates inhibit an enzyme 7-alpha something (sorry cnt really remember the name)

That enzyme normally, breaks down nonbile acid soluble cholesterol to Bile salt soluble cholesterol.

therefore, fibrates inhibit this enzyme and causes excess of insoluble cholesterol in gall bladder and cause super saturation causing cholesterol stone!

This is 1 important concept i learn from UW.


correct me if am wrong! :sorry::sorry::sorry::sorry::sorry:
It works on PPARα and increases the amount of LPL.
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