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Old 04-16-2012
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Biochemistry Glucose to Glucose-6-Phosphate!

is it true that glucose is immediately metabolised to G-6-P to prevent its escape from cell? i remember reading it somwhere :-/
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Old 04-16-2012
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well if its true than its done by hexokinase (or glucokinase in liver and pancreas [higher km]) it's irreversible step, so if it gets in it cannot come out.
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Old 04-16-2012
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yes.
&
frustose metabolism is faster than glucouse cz it doesnot have the rate limiting step. --- > just an FYI
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Old 04-16-2012
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so then why does hyperglycemia cause Increase In POsm and therefore shift of fluid from ICF to ECF??? (Isnt it all trapped inside the cell?) am i missing something here :-/
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So thats why its ok to give fructose to diabetics. It bypasses to the hexokinase/glucokinase step regulated by insulin.
I just came up with it yesterday... simple for someone, but for me it was out of the blue
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Quote:
Originally Posted by vna.rao22 View Post
so then why does hyperglycemia cause Increase In POsm and therefore shift of fluid from ICF to ECF??? (Isnt it all trapped inside the cell?) am i missing something here :-/
HyperglycEMIA - its glucose in the blood... swimming and increasing osmolality by its presence...

its not trapped. Insulin is either deficient or there is resistence to it. So the trap is not doing its job => hyperglycemia
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Old 04-16-2012
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aahh, makes sense now! Phew! excess-studying/thinking can make you go crazy!
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Originally Posted by vna.rao22 View Post
aahh, makes sense now! Phew! excess-studying/thinking can make you go crazy!
it can make you Siko!
=)
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Quote:
Originally Posted by DocSikorski View Post
HyperglycEMIA - its glucose in the blood... swimming and increasing osmolality by its presence...

its not trapped. Insulin is either deficient or there is resistence to it. So the trap is not doing its job => hyperglycemia
to add up
to trap its should be absorbed ,which is defective.
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Originally Posted by Kabutar111 View Post
to add up
to trap its should be absorbed ,which is defective.
please explain
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Quote:
Originally Posted by DocSikorski View Post
please explain
Trap is defective if problem with glucokinase(anyone know such problem??) not when insulin problem as its responsible for absorption. Not intrapment.

Also glucokinase is special due to its very low Km value .
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Quote:
Originally Posted by Kabutar111 View Post
Trap is defective if problem with glucokinase(anyone know such problem??)
There is a congenital form of diabetes (MODY2) that's caused by a deficiency of glucokinase.
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