Clomiphene; when do we use it continuously? - USMLE Forums
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Old 04-16-2012
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Drug Clomiphene; when do we use it continuously?

just popped in my head as i was reading about miscarriages

clomiphene we give pulsatilely to increase LH and FSH so we use it for infertility or PCOS.

when would we use it continuously? in ER-breast cancer maybe? in endometrial carcinoma?
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Old 04-17-2012
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100 views and no answer. You really stumped everyone Dr. Nick.
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Old 04-17-2012
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I didn't know that clomiphene is given "pulsatilely". Isn't the whole point of clomiphene to block the feedback inhibition?
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Old 04-17-2012
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Quote:
Originally Posted by kcub View Post
I didn't know that clomiphene is given "pulsatilely". Isn't the whole point of clomiphene to block the feedback inhibition?
no, its point is to make women being able to concieve as she is infertile coz of PCOD and too much LH..
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Old 04-17-2012
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i wonder is it has anything to do with their secretion because it amplifies them by acting on LH n FSH receptors in Hypothalamus. A GnRH analog would have different effects in pulsatile n continuous manner because it acts on Pituatry receptors. but not the agent which is a partial agonist on the receptors in HYpothalamus.Kindly correct me because i myself am confused now i guess...
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Old 04-17-2012
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Continuous Tamoxiphene rx is used for ER +ve Breast Ca

Tamoxiphene/clomephene increases risk of EM ca, so they won't be used for its Rx
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Old 04-17-2012
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Quote:
Originally Posted by kcub View Post
I didn't know that clomiphene is given "pulsatilely". Isn't the whole point of clomiphene to block the feedback inhibition?
you might be on to something
the exact mechanism isnt very well described in any of the main sources but i remember from my med school that it inhibits negative feedback on the pituitary and thus theres a continuous secretion of LH, FSH.

so it takes away the regulation that would see LH, FSH decrease at times.

so i guess its just given the way it is, neither continuously or pulsatily, since it is in fact not a a GnRH analog.

good job kcub!
alot of ppl got stumped by this hehe
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