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Old 03-24-2016
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Default receptor tyrosine kinase vs non receptor tyrosine kinase?

can someone please simplify the differences (with some examples) for me please?
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Old 6 Days Ago
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There are two concepts here you are talking about:
1. Tyrosine-Kinase-Receptors
- Mostly Growth Factors and Insulin
2. Tyrosine-Kinase-Associated Receptors
- Mostly for Cytokines, Growth Hormones, Prolactin, BC-R and TC-R is of same type

1: After binding of the ligand (GFactor), this receptor can autophosphorylate its Tyrosine residues --> activation of GRB2 --> activation of SOS-proteins --> Activation of RAS and it's downstream signalling kinases (like Raf-Kinase, MAP-kinase) --> activation of Transcription Factors which translocate into the nucleus


2: After binding of the ligand (Cytokines), this receptor dimerizes --> Tyrosine Kinases (which are called JAKs) are recruited --> these JAKs crossphosphorylate the dimer --> this leads to activation and Dimerization of STAT which translocates into the nucleus and causes Transcription

difference between 1 and 2:
1 can autophosphorylate, it has intrinsic Tyrosine Kinase activity
2 has to recruit JAK, which does the Kinase activity

this is from SDN forum
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