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Old 04-20-2012
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Show Teeth Fastest signaling pathway?

I thought steroids have the fastest receptors because they have cytosolic or nuclear receptors and they are lipophilic, but Im wrong.

Between cAMP, cGMP, IP3, Tyrosine kinase (intrinsic or receptor associated), which is the fastest??? Which is the slowest???

Please help, thank you
(2012 FA pg 321)
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Old 04-20-2012
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Hi, I wont ask why is it important as it's not my bussiness

Its not about who's the fastest but who works in which way, Tyrosine kinases usually work through proteins that eventually affect DNA transcription (there are exceptions e.g proteins that are activeted directly for example Glycogen synthase by insulin). hence you get both fast and slow response.

cAMP activates PKA which produces fast response by phsphorylating different proteins, but also activates CREB who works though DNA and has a slow response.

cGMP and Gq (IP3 DAG) mainly work on proteins and less on DNA so they usually get a fast response.

So again for your question anything the works on DNA modulation has slower response - and thats why Steroids are so slow acting.

AND usually those 2messenger systems you were speaking about have both fast and slow response phase.
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Muzzy (04-21-2012)
Old 04-21-2012
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I actually came across a question which essentially asked which is the fastest. If I come across it again I'll make sure I post it. Thanks for the great explanation.
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Biochemistry-, Cell-Biology-, Molecular-Biology-

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