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Old 05-07-2010
Yallah's Avatar
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Neuro Etiopathogenesis of CNS Lesion

A 56-year-old man who's right-handed came to the physician because of 2 months history of increasing clumsiness in his right hand and difficulty finding words. Physical examination showed UMN lesion of the right upper extremity and difficulty with naming and repetition. An MRI of the brain showed an infiltrating left frontal mass. Analysis of stereotaxic biopsy specimen shows a grade II astrocytoma. Impaired activity of which of the following proteins is the most likely cause of this lesion?

A- Cyclin D
B- p53
C- Ras
D- ret
E- Tyrosine kinase A
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Old 05-07-2010
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Mutation of the p53 tumor suppressive peptide is the most usual suspect underlying almost any malignancy. In particular, it is evident in almost 2/3 of pt's suffering from astrocytoma.
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