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Old 04-22-2012
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Drug Action of ergotamine (doubt)

Kaplan says ergotamine is a partial agonist at 5ht2 receptors which is the basis of being an anti migraine agent.

Lipincott doesnt say anything bout ergotamine, but says dih2ergotamine is 5ht1D agonist.

Wikipedia says ergotamine is 5ht1b/1d agonist. Wiki is never wrong in my experience.

Does anybody know if kaplan is wrong in this regard?
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Old 04-22-2012
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I think ergotamine is non-selective - theoretically it could affect migraines through 1a, 1d, 2a... I don't know if we know what the main effect is from.
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Old 04-22-2012
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Sumatriptan is the 5-hT1d agonist

Ergometrin acts as alpha and 5-ht2 partial agonist as said in Kaplan .. I guess it's the combined action that's beneficial in migraine
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yeah not only 5ht2 but also alfa agonist so reverse the vasodilation.....so as true as kaplan says
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Old 04-23-2012
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Thanks for the reply guys.

I was just worried cos wikipedia is never wrong in my experience.
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