Aplastic anemia versus myeloproliferative disorder - USMLE Forums
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Old 04-23-2012
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Blood Aplastic anemia versus myeloproliferative disorder

what is the difference between aplastic anemia and myeloproliferative disorder , how to deffrentiate in diagnosis??
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Old 04-24-2012
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Aplastic anaemia- pancytopenia, cell in p/s are normal, bone marrow is hupocellular

Myloproliferative disorder- Pancythemia, there might be abnormal cells on p/s, hyper cellular bone marrow
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Old 04-24-2012
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I would add the myeloprolifrative disorders involve as a group activating mutation in their tyrosine kinase signaling pathway which leads to over prolifration of these cells. in CML it's abl-bcr translocation that transcripts for abnormal tyrosine kinase, while in the other 3 PV, ET and myelofibrosis there is an activating mutation on a tyrosine kinase that is called jak kinase V617.

thats why these diseases are found under the same catagory , and altough myelofibrosis can lead to aplastic anemia because of it's activating mutation it's still under this group of diseases.

aplastic anemia can be caused due to drugs, infections (viruses) can be idiopathic or gentic. and as the one before me wrote it's associated with hypoplastic bone marrow.
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Old 04-24-2012
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aplastic anemia - produce less blood cells
myeloproliferative disorders - produce too many blood cells (ie. polycythemia vera).
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Old 04-24-2012
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Quote:
Originally Posted by Dr.NickRiviera View Post
aplastic anemia - produce less blood cells
myeloproliferative disorders - produce too many blood cells (ie. polycythemia vera).
that is pretty much enough, and this is clear from the term itself

Mary -i don't think anyone cares about the thank but still , we are in profession of character, and you have point
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