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Old 04-24-2012
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Question Are Diabetics Immunocompromised?

In FA 2012 pg 273, for one of the causes of oral thrush it has diabetes.

Are diabetics immunocompromised? Is it both type 1 and 2 diabetics?
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Old 04-24-2012
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yes diabetic patients are immunocompromised, as are the children and the old people, as are pregnant women and alchoalic patients they all fit in the catagory.

all of this for example have a risk of opportunistic fungal infection.

please make a distinction between immunocompromised and immunosuppressed patients - HIV (cd4 200-500) and transplant patinets they have a very low immune response so they get other more disabling diseases.
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Old 04-24-2012
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why are diabetics IC?
T1 or 2?

Does it only happen with Diabetic Ketoacidosis (eg with Mucor)?
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Old 04-24-2012
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Both of them are IC, one the reasons is high glucose levels of the blood that alot of organisms like (ofcourse if it's poorly controlled DM), DM1 associated with mucor that's right usually the ketoacidotic patients because of the very high glucose levels. the other reason might be the angiopathy which damages the blood supply and heance the white blood cell supply to different tissues in our body hence reducing the ability to fight different infections, a big thing to remember that the integrins on endothelial cells are downregulated in diabetes which also damages the migration of neutrophils to site of infection. Another thing is the increased oxidative stress on cells in diabetes damages membranes some of this membranes are of white blood cells which become less functional. As you see there are alot of reasons - what USMLE can specifically ask you is the lack of adhesion which can be similar to Leukocyte adhesion deficiency, i also add that alcoholic patients also show the same problem with adhesion.
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