What's the difference between Neuroendocrine and Paraneoplastic? - USMLE Forums
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Old 04-25-2012
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Question What's the difference between Neuroendocrine and Paraneoplastic?

Both secrete things, right?

are they interchangeable terms?

What is the exact definition of either?
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Both secrete things.
They are not interchangeable terms.

Carcinoid - think carcinoma like. Carcinoid tumors contain neurosecretory granules that secrete Serotonin. This serotonin is released into the portal circulation and it gets metabolized by the liver and increases 5-HIAA levels in the urine.

Carcinoind SYNDROME - is when you have metastases of the carcinoid tumor TO THE LIVER where it secretes the serotonin into the HEPATIC vein (which then IVC, RA, RV -> Pulmonary circulation n then LA, LV -> Systemic circulation). So you can see here, the serotonin is not metabolized and it goes around the body as Serotonin. That is why you get the symptoms such as Wheezing, Diarrhea, facial flushing etc).


Paraneoplastic - these are carcinomas that secrete localized substances or related peptides that are functional. For example, EPO (causing polycythemia vera), ACTH(causing cushings) or PTHrP (causing hyperparathyroidism) secreted by RCC.
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Quote:
Originally Posted by Hope2Pass View Post
Both secrete things.
They are not interchangeable terms.

Carcinoid - think carcinoma like. Carcinoid tumors contain neurosecretory granules that secrete Serotonin. This serotonin is released into the portal circulation and it gets metabolized by the liver and increases 5-HIAA levels in the urine.

Carcinoind SYNDROME - is when you have metastases of the carcinoid tumor TO THE LIVER where it secretes the serotonin into the HEPATIC vein (which then IVC, RA, RV -> Pulmonary circulation n then LA, LV -> Systemic circulation). So you can see here, the serotonin is not metabolized and it goes around the body as Serotonin. That is why you get the symptoms such as Wheezing, Diarrhea, facial flushing etc).


Paraneoplastic - these are carcinomas that secrete localized substances or related peptides that are functional. For example, EPO (causing polycythemia vera), ACTH(causing cushings) or PTHrP (causing hyperparathyroidism) secreted by RCC.
so how is a neuroendocrine tumor different? whats the definition of neuroendocrine?
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Quote:
Originally Posted by Dr.NickRiviera View Post
so how is a neuroendocrine tumor different? whats the definition of neuroendocrine?
As the name suggests - NEURO-ENDOCRINE tumor .. so tumors arising from the endocrine or nervous system.
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so a neuroendocrine tumor can be a paraneoplastic tumor but a paraneoplastic tumor isnt necessarily a neuroendocrine tumor?

we'd call Small Cell CA and Squamous Cell CA of the lung paraneoplastic tumors, not neuroendocrine tumors?
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Quote:
Originally Posted by Dr.NickRiviera View Post
so a neuroendocrine tumor can be a paraneoplastic tumor but a paraneoplastic tumor isnt necessarily a neuroendocrine tumor?

we'd call Small Cell CA and Squamous Cell CA of the lung paraneoplastic tumors, not neuroendocrine tumors?
Small cell CA or Squamous cell CA .. these are CARCINOMAS ...epithelial origin. So these are classified as carcinomas not neuroendocrine tumors that have nervous or endcrine origin.

Paraneoplastic secrete neurotransmitters or substances like those that they generate in the neurosecretory granules.

Anyways thats my understanding lol
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Originally Posted by Hope2Pass View Post
Small cell CA or Squamous cell CA .. these are CARCINOMAS ...epithelial origin. So these are classified as carcinomas not neuroendocrine tumors that have nervous or endcrine origin.

Paraneoplastic secrete neurotransmitters or substances like those that they generate in the neurosecretory granules.

Anyways thats my understanding lol
what's your understanding of Chromogranin stain?
I was taught in Kaplan that SCC and SqCC of the lung stain + for it because they are paraneoplastic.
But wiki says its a stain for Neuroendocrine tumors :S
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Originally Posted by Dr.NickRiviera View Post
what's your understanding of Chromogranin stain?
I was taught in Kaplan that SCC and SqCC of the lung stain + for it because they are paraneoplastic.
But wiki says its a stain for Neuroendocrine tumors :S
Yeah, I was looking at that too...

You can read through this n see if you find anything - http://erc.endocrinology-journals.or...17/3/R173.full
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Neuro endocrine cells present in diff parts of the body secrete primarily the Harmones. Tumor arinsing for them Is carcinoid .

Effects of the same Carcinoid syndrome/ paraneoplastic syndrome !! correct me if I'm wrong
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