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Old 04-26-2012
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Blood Trisomy 21 Hematogical Abnormality

A- Acute lymphocytic leukemia
B- Acute megakaryoblastic leukemia
C- Disseminated Intravascular Coagulation (DIC)
D- Polycythemia
E- Transient myeloproliferative disorder


Your explanation is always welcome, and please read carefully before answering!

Trisomy 21 Hematogical Abnormality-trisomy-21.png
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Old 04-26-2012
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A. ALL is the answer
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Angry

I answered that too, but it was wrong
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Old 04-26-2012
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Is it D? In Goljan audio lecture he mentioned it.
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Quote:
Originally Posted by islandcrazy View Post
Is it D? In Goljan audio lecture he mentioned it.
It will be better for us in this forum if you write what Goljan was mentioned, what do you think?
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Quote:
Originally Posted by alfjof View Post
It will be better for us in this forum if you write what Goljan was mentioned, what do you think?
I can't remember the details as I did not take notes, what I remember is Goljan stated in the heme lecture that a percentage of Newborns with Trisomy 21 have polycythemia. He doesn't go into any detail he simply stated it.
Here is a link I googled from childerns Hospital of Pittsburg.

Quote:
Who is affected by polycythemia?
Polycythemia may occur with many different conditions. Some of the babies affected by polycythemia include:

those born at high altitudes because of the greater demand for blood to carry oxygen.
those born after 42 weeks gestation.
small for gestational age (SGA) / intrauterine growth restriction (IUGR).
identical twins who share a placenta and develop twin-to-twin transfusion.
infants of diabetic mothers.
those with chromosomal abnormalities including trisomies 13, 18, and 21 (Down syndrome).
http://www.chp.edu/CHP/P02398

By the way is that the right answer?

Last edited by islandcrazy; 04-26-2012 at 07:28 PM. Reason: Forgot Link
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A. Ac lymphoblastic leukemia n
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You're right, and the answer is D. All patient born with Trisomy 21 have an high percent to do MEGALOBLASTIC POLYCYTHEMIA in 75%, contrast to all in this forum know is ALL, which is 10%, and AML-M7(due to AMKL protein) in 7%. I never knept the case of: Polycythemia and AML. If I am wrong please correct me
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Quote:
Originally Posted by alfjof View Post
You're right, and the answer is D. All patient born with Trisomy 21 have an high percent to do MEGALOBLASTIC POLYCYTHEMIA in 75%, contrast to all in this forum know is ALL, which is 10%, and AML-M7(due to AMKL protein) in 7%. I never knept the case of: Polycythemia and AML. If I am wrong please correct me


You're correct. I have seen this type of question.
the thing is that The most common leukemia in down patients is ALL and than AML M7. but most common Myeloid Neoplasm in down patients is Polycythemia.
So Poly >> ALL > AML M7

Check this link : http://findarticles.com/p/articles/m.../ai_n27484532/
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Old 04-27-2012
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No problem keep studing
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Old 07-09-2014
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polycythemia vera
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Old 09-22-2014
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Correct Answer

Quote:
Originally Posted by alfjof View Post
A- Acute lymphocytic leukemia
B- Acute megakaryoblastic leukemia
C- Disseminated Intravascular Coagulation (DIC)
D- Polycythemia
E- Transient myeloproliferative disorder


Your explanation is always welcome, and please read carefully before answering!

Attachment 2488
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its B , the most comon is AML M7 . that is magakaroblastic leukemia
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Old 09-22-2014
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P. vera is a Myeloproliferative disorder. Now, in Rapid Review Pathology 4th Ed. it says they develop Transient Myeloproliferative Disorder. So, now I'm confused because both of these options are there. What's the difference?
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Old 11-21-2014
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it depends on the age
below 5 yrs acute megakaryocytic leukemia
above 5 yrs acute lymhocytic leukemia

pathoma
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