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  #1  
Old 04-27-2012
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Drug Parkinson drug

self made, watch out for mistakes (they are possible)
==================================

55-year old woman had her last menstrual period 5 years ago. She has noticed a discharge from her nipples and CT of the head showed a mild enlargement of suprasellar structure, receiving its hormonal input from paraventricular and supraoptic nuclei. You begin the treatment with the drug regimen that is also used in parkinson disease. What is the downstream mechanism of the drug, seen within the target cell?

a. increase in Ca++
b. increase in Na+
c. increase in cAMP
d. decrease in K+
e. decrease in NO
f. decrease in Cl-

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Old 04-27-2012
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ok so u mean bromocriptine?

is it a question asking about the g-protein 2nd messengers for dopamine or something?

well there's
D1 ---> s
D2 ---> i

QISS and QIQ till ur SIQ of SQS

I feel like i complicated the hell out of this question
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Old 04-27-2012
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Quote:
Originally Posted by DocSikorski View Post
enlargement of suprasellar structure, receiving its hormonal input from paraventricular and supraoptic nuclei.
so we talking about the posterior pituitary?
well it secretes ADH and oxytocin.

I cant think of a connection between them and Parkinsons :S
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Old 04-27-2012
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maybe he ment periventricular no?
it should decrease cAMP (D2 Gi) but again i cant find the right answer, the other ions also dont fit.
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assume "all-pituitary" is enlarged
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Old 04-27-2012
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Quote:
Originally Posted by DocSikorski View Post
assume "all-pituitary" is enlarged
Its most likely a pituitary adenoma secreting Prolactin (prolactinoma). If I remember correctly, one of the D receptors works in the brain and the other in the kidney. I can't recall which one. (look at Renaissance's explanation of the D receptors).

Since D2 receptors use Gi receptors that would decrease Camp . .but thats not an answer choice So I'd go with D1 receptors that use C) Gs = INCREASE IN CAMP.

Is that correct?
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Old 04-27-2012
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ok so maybe theres too much prolactin so you start using bromocriptine.

and as such, the dopamine receptors are stimulated, namely D1 because you want an increase in dopamine.
and its prolly Gs coupled
so C. increased cAMP ?
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Old 04-28-2012
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wow, looks like im not the only one who tends to complicate the sh!t out of questions
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Old 04-28-2012
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so you guys got there, but not quite...

So yes, its prolactinoma.
Dopamine downregulates prolactin, so you reach for Bromocriptine, which acts as dopamine itself, binding D2 receptor.

After D2 is activated, cAMP levels decrease and K+ is pumped out of cell further repolarizing it.

@Renaissance - thanks for the mnemonic!:


"KISS and KICK till you're SICK of SEX" (QISS and QIQ till you're SIQ of SQS):
This gives the G-protein type (Gq, Gi, or Gs) for all the receptors. Receptors are in alphabetical order:
alpha1=Q
alpha2=I
beta1=S
beta3=S
M1=Q
M2=I
M3=Q
D1=S
D2=I
H1=Q
H2=S
V1=Q
V2=S
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