Bernard-Soulier; why thrombocytopenia? - USMLE Forums
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Old 04-27-2012
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Blood Bernard-Soulier; why thrombocytopenia?

FA 2011 pg. 355

Bernard-Soulier has decreased Platelet Count... why?
Platelets can't bind to the endothelium, thats the defect. Nothing to do with a decrease in platelet count.

ITP and TTP i can understand because they are being destroyed and are consumed in thrombosis.
"inflammable means flammable!? What a country."
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Old 04-27-2012
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I actually remember asking the same question in class months ago and couldn't think of the answer I I searched:

It is a type of Giant Platelet syndromes and due to the possibility that when the platelet count is performed with automatic counters, giant platelets, which may be as frequent as 70–80% in occasional patients, may reach the size of red blood cells and, as a consequence, are not recognized as platelets by the counters.

- wikipedia
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Desmin (01-31-2017), Rookie (04-28-2012)


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