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Old 04-28-2012
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Question I cell disease question

I have trouble understanding, where are normally mannose residues are phosphorylated? RER or Golghi?

different sources tell me different stuff.
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they are phosphorylated in the golgi which traffics them to the lyzozoms.
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Quote:
Originally Posted by modesty View Post
they are phosphorylated in the golgi which traffics them to the lyzozoms.
which makes sense, right?
cuz if they are not phosphorylated, they are pumped out of cell.
If it was RER that would be too long of a road
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the glycosylation(addition of oligosacchride side chain) occurs in the transit from ER to golgi.

Phosphorylation of the mannose residues in these oligosacchride chains(of whatever protiens/enzymes that have to reach the lysosomes) occurs in the Golgi.

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Golgi is the post synthesis processing unit , out of two .
that means it should be performing the final step of process .
which is you are asking in this.
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golgi apparatus.
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