Myometrium in pregnancy - hyperplasia or hypetrophy? - USMLE Forums
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Old 04-29-2012
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Heart Myometrium in pregnancy - hyperplasia or hypetrophy?

Hey guys!

I have just started watching Pathoma video on Neoplasia and bam! it hit me with an information that left me confused... They say that in pregnancy myometrium undergoes hyperplasia

In Robbins and Cotran Review of Pathology (3rd edition, Chapter 1, question 32) they say that myometrium undergoes hypertrophy.. And that's what I have always thought.

I thought that in pregnancy:
- endometrium undergoes both hyperplasia and hypertrophy (it's pretty intuitive that both the number and the size of the glands and blood vessels increase)
- myometrium - only hyperthrophy (as after the delivery it contracts to expel the placenta and to minimalize the blood loss - so I thought that there's only increase in size of the cells).

Now I'm confused... Can anyone please help me out with this?
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hyperplasia , was my wrong answer .
i still think smooth muscle hv limit for hypertrophy .

hope someone enlighten me here
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Old 04-29-2012
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Default Goljan

"(...)example - enlargement of the gravid uterus due to smooth muscle hypertrophy (and hyperplasia) from estrogen stimulation"
Source: Goljan RR (Chapter 1) ...

so myometrium undergoes both?

@Kabutar111 - Smooth muscle are stable type of cells - they can undergo both hyperplasia and hypertrophy...
The question you are talking about was asking what contributed most to the increase in uterine size - so it was myometrial smooth muscle hypertrophy. And it's correct.

What I'm asking about here is a different story. Does myometrium undergo hiperplasia as well?

Last edited by Casandra; 04-29-2012 at 04:01 AM.
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I answered Robbin's Q and A last week and I know the question and explanation you're referring to. I also just read that part in Goljan around the same time. I didn't really notice the discrepancy, but you are right. These sources are conflicting.

Anyway, if it comes up in the exam, I'll choose hypertrophy over hyperplasia. But if there's a choice that says hypertrophy AND hyperplasia, then, I'll choose the one that says both.
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Quote:
Originally Posted by Casandra View Post

What I'm asking about here is a different story. Does myometrium undergo hiperplasia as well?
Since the myometrium is a smooth muscle, to some extent it undergoes hyperplasia. But I think the hypertrophic change is more predominant.
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Quote:
Originally Posted by d_wiqed View Post
Anyway, if it comes up in the exam, I'll choose hypertrophy over hyperplasia. But if there's a choice that says hypertrophy AND hyperplasia, then, I'll choose the one that says both.
I'm with you on that one
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Quote:
Originally Posted by d_wiqed View Post
Since the myometrium is a smooth muscle, to some extent it undergoes hyperplasia. But I think the hypertrophic change is more predominant.
ok, that sounds reasonable I asked the question as I freaked out that my way of thinking about this issue was crappy. thanks d_wiqed
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Quote:
Originally Posted by Casandra View Post
ok, that sounds reasonable I asked the question as I freaked out that my way of thinking about this issue was crappy. thanks d_wiqed
thank you now my way of thinking is crappy
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Quote:
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thank you now my way of thinking is crappy
naaaaaa. but I always tell myself: there's always room for improvement
studying for step 1 makes this room bigger and bigger every day for me haha
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