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Old 04-29-2012
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Drug Where is the site of action of Mannitol?

In KLN videos- it was said that mannitol (osmotic diuretic) acts on the whole length of the nephron but the predominant effect is seen on PCT but in FA 2012 pg 524 its given as loop of Henle?

I checked in wikipedia and its given PCT as the major site of action of osmotics..
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I don't remember Kaplan videos, but yes from fa remember same.
But I think it will in work both places as these being primary sites of water absorption
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Ok I am probably way off here but isn't mannitol's main action on the Proximal tubule which blocks the Na+/Ca+2 symporter or something like that .. or did I just make that up ? lol
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Originally Posted by Hope2Pass View Post
Ok I am probably way off here but isn't mannitol's main action on the Proximal tubule which blocks the Na+/Ca+2 symporter or something like that .. or did I just make that up ? lol

I think you did
It's osmotic diuretic .
Take regular breaks ,I know your study plan is hard but still take breaks
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I think you did
It's osmotic diuretic .
Take regular breaks ,I know your study plan is hard but still take breaks
AH I knew it ... well time to go back n review some stuff on mannitol lol
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AH I knew it ... well time to go back n review some stuff on mannitol lol

Dude breaks
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Dude breaks

took one yesterday, may be that's why im a little out of it .. just got up haha
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Originally Posted by Hope2Pass View Post
took one yesterday, may be that's why im a little out of it .. just got up haha
Well that explains it
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As far as i remem from kaplan...he says osmotic diuretics act to draw water into the lumen mainly in the PCT since max reabsorption of water in the whole tubule occurs in the PCT along with Na,HCO,Cl. i guess around 65%. going by this answer should be PCT and this seems more sensible to me......
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Pct has got large surface area of absorption for solutes subsequent H2O movement across the membrane , as mannitol is osmotic diuretic it decreases absorption mainly in this region of nephron causing diuresis
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Originally Posted by anomali View Post
As far as i remem from kaplan...he says osmotic diuretics act to draw water into the lumen mainly in the PCT since max reabsorption of water in the whole tubule occurs in the PCT along with Na,HCO,Cl. i guess around 65%. going by this answer should be PCT and this seems more sensible to me......
But water absorption against coc gradient mainly in loop ,if I remember correctly,
So it makes more sense for osmotic drug to work in this region ALSO .
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But water absorption against coc gradient mainly in loop ,if I remember correctly,
So it makes more sense for osmotic drug to work in this region ALSO .
What ur saying is correct too....ill enquire on this from other sources and hopefully able to reach a consensus. will post here after i get a concrete answer from a reliable source!!!!!!!!!!
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