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Old 05-15-2010
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Thyroid 40 year old man with hypercalcemia

A routine physical examination demonstrates hypercalcemia in a 40-year-old man. Circulatory levels of parathyroid hormone are also elevated. Exploratory surgery of the neck reveals diffuse hyperplasia of all four parathyroid glands. Which of the following screening studies would most likely be helpful in confirming the diagnosis of multiple endocrine neoplasia, type I (MEN I)?

A. Pentagastrin-simulated calcitonin secretion
B. Serum epinephrine
C. Serum gastrin
D. Serum norepinephrine
E. Urinary adrenaline:noradrenaline ratio
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  #2  
Old 05-15-2010
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Default C. serum gastrin

Gastrinomas are found in approximately 60% of patients with MEN 1
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Old 05-15-2010
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Default C. Serum gastrin ?

Quote:
Originally Posted by sam01 View Post
A routine physical examination demonstrates hypercalcemia in a 40-year-old man. Circulatory levels of parathyroid hormone are also elevated. Exploratory surgery of the neck reveals diffuse hyperplasia of all four parathyroid glands. Which of the following screening studies would most likely be helpful in confirming the diagnosis of multiple endocrine neoplasia, type I (MEN I)?

A. Pentagastrin-simulated calcitonin secretion
B. Serum epinephrine
C. Serum gastrin
D. Serum norepinephrine
E. Urinary adrenaline:noradrenaline ratio

C. Serum gastrin ?
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  #4  
Old 05-15-2010
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yes i think the ans is C . pancreatic endocrine tumor ( zollinger -Ellison syndrome) is a gastrin secreting tumor . everyother choice is for mens 11A
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  #5  
Old 05-15-2010
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Default C

yup i also select C serum gastrin...
MEN 1...
Wermer's syndrome
Tumors of 3 Ps: Pancreas, Pituitary,
and Parathyroid
in pancreas it is a Gastrin producing pancreatic adenoma...(ZE Syndrome)
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  #6  
Old 05-17-2010
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yep.u re ryte.
In multiple endocrine neoplasia, type I (MEN I), parathyroid hyperplasia and/or adenomata are associated with pancreatic and duodenal endocrine tumors and endocrine hyperplasia. The most common secretory product of the pancreatic and duodenal endocrine lesions is gastrin. Pituitary adenomata may also occur in MEN I.
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