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Old 05-02-2012
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Question Neurotransmitters Effects on Appetite!

Hey guys..
What is the relationship between appetite and NE, DA and Serotonin. It confuses me a lot. I'd be grateful to anyone who can clear that for me..
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Old 05-02-2012
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increased levels of NE, 5HT3 or Dopamine cause ummmmm i think hunger, and hence weight gain.

i always get confused about this too.
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Old 05-02-2012
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not sure.
take an example of a regular rave guy - skinny as hell!

amphetamines cause release of NE, serotonin (not sure about dopamine), but they never want to eat.

Amphetamines are used to get skinny, so I guess NE (flight or fight) is more on a satiety site
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Old 05-04-2012
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It is sorta confusing. At some places u get a feeling serotonin makes u hungry and then at orher places u feel the opposite!!
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Old 05-04-2012
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All three normally suppress appetite.

DA and 5HT are involved in satieity (reward), and their disfunction can cause excessive food consumption/obesity because the person never gets the feeling of fullness ('the itis').

Should be the same for NE, since Ach normally increases appetite and NE is involved in the sympathetic response so it must suppress appetite.

Random fact: 5HT also goes up after a meal, due to increased tryptophan in blood, and this is part of the reason we get the 'itis'. Also when EC cells lining the intestines are irritated by so noxious stimuli in the GIT, it releases a flood of 5HT which can increase motility (get rid of the noxious stimuli via diarrhea) and also stimulate the CTZ to cause vomiting (again get rid of the bad stuff in our GIT).
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Old 05-04-2012
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how do neuroleptics cause weight gain?

they block the receptors, so shouldnt the circulating levels of these neurotransmitters increase? which you say causes suppression of appetite (and therefore weight loss)?
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Quote:
Originally Posted by Dr.NickRiviera View Post
how do neuroleptics cause weight gain?

they block the receptors, so shouldnt the circulating levels of these neurotransmitters increase? which you say causes suppression of appetite (and therefore weight loss)?
stimulators (methamphetamine) =/= neuroleptics
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Quote:
Originally Posted by DocSikorski View Post
stimulators (methamphetamine) =/= neuroleptics
what????? lol
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Quote:
how do neuroleptics cause weight gain?

they block the receptors, so shouldnt the circulating levels of these neurotransmitters increase? which you say causes suppression of appetite (and therefore weight loss)?
??? I don't know if i understood the question right.. but if the neuroleptics are blocking the DA or 5HT receptors then isn't it just inhibiting the action of those neurotransmitters. Since DA and 5HT can't act on their receptors then the person wouldn't really feel satiated and this would lead to over consumption and weight gain??
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Quote:
Originally Posted by slowpoke View Post
??? I don't know if i understood the question right.. but if the neuroleptics are blocking the DA or 5HT receptors then isn't it just inhibiting the action of those neurotransmitters. Since DA and 5HT can't act on their receptors then the person wouldn't really feel satiated and this would lead to over consumption and weight gain??
i was thinking that, but then i was thinking that specific receptors in specific areas of the brain are being blocked.
ie. dopamine receptors are blocked in the mesolimbic and mesocortical areas but not say ummm the substantia nigra, so by this logic the areas mediating hunger/satiety are also not being blocked?

i dont know, im confused.
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