Nephron Loctation and Spironolactone - USMLE Forums
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Old 05-17-2010
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Anatomy Nephron Loctation and Spironolactone

A 43-year-old male presents to his primary care doctor with complaints of increasing abdominal girth. He has a long history of alcohol abuse and recently stopped drinking. Spironolactone is prescribed to aid in control of the patientís increasing ascites. Which of the following is the site of action of spironolactone?

A) Ascending loop of Henle
B) Collecting duct
C) Descending loop of Henle
D) Distal tubule
E) Proximal tubule
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  #2  
Old 05-17-2010
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Default B

B) Collecting duct
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Old 05-17-2010
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i think its collecting duct but i did this question before somewhere and it says distal tubule
cant think where i did it
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Old 05-17-2010
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i m sure its collecting duct

@ freaking out where did u see this question
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Old 05-17-2010
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I think its late distal tubule and collecting duct, but since we have to choose one we choose collecting duct.

The most recent Kaplan Pharm book shows aldosterone receptors in the collecting duct under this topic but if you look at the wiki entry for aldosterone it says they're present in principal cells in both the collecting and the distal convoluted tubule... Since spironolactone is an aldosterone antagonist it follows that it should work where the aldosterone receptors are so that may be the source of the confusion.

I think generally though, if you see this, you go with collecting duct.
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aldosterone receptors are present where is it distal tubule or CT or both????
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i think it's early part of collecting duct.
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Old 05-17-2010
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somebody who exactly knoe plzzz explain
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