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Old 05-05-2012
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Question Secondary endocrine disorders and receptor downregulation.

Hi all,

I had a question: as we read whenever there's pathological excess production of pituitary hormones like ACTH/TSH (antibody) etc.., why don't their target receptors downregulate with such huge chronic stimulation (as normally happens) and put an end to their pathologic peripheral effects over time? It is not that in secondary disorders receptors are affected. Or is it the disease saying, ''Hey humans u don't need to know everything about me.''
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Old 05-05-2012
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they probably do downregulate a bit but only to a point as to avoid anything over maximal stimulation of that pathway. maximal stimulation of that pathway is still ok as far as the bodys concerned because it just assumes its in a state where maximal effect is needed, and hence lies the pathology; being in a state of maximal effect when its not needed. anything above this maximal effect would cause the receptors to downregulate.

atleast, thats my logic lol
"inflammable means flammable!? What a country."
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Endocrine-, Pathology-

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