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  #1  
Old 05-18-2010
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DNA Family with mild mental retardation in children

A family is referred to a genetic specialist because of mild mental retardation in several of the school-age children. Laboratory evaluation demonstrates a specific chromosomal breakage site in metaphase studies of lymphocytes cultured with methotrexate. Which of the following chromosomes is most likely to be specifically affected?
A. X
B. Y
C. 13
D. 16
E. 21
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  #2  
Old 05-18-2010
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Default

A-X ( Fragile X syndrome)
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  #3  
Old 05-18-2010
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Default A

A) X
most probably its a fragile X syndrome...
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Old 05-18-2010
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i will go with A
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Old 05-19-2010
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Default Choice A.

The heritable mental retardation condition associated with chromosomal breakage is fragile X syndrome. The break point is at q27.3 on the X chromosome. The test for this condition involves culturing lymphocytes in either folate-deficient medium or with chemical agents such as methotrexate that tend to break chromosomes. To make the diagnosis, at least 4% of metaphase chromosomes must show the specific break-point on the X chromosome.
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