Phenobarbitone / Gilbert's syndrome relation ? - USMLE Forums
USMLE Forums Logo
USMLE Forums         Your Reliable USMLE Online Community     Members     Posts
Home
USMLE Articles
USMLE News
USMLE Polls
USMLE Books
USMLE Apps
Go Back   USMLE Forums > USMLE Step 1 Forum

USMLE Step 1 Forum USMLE Step 1 Discussion Forum: Let's talk about anything related to USMLE Step 1 exam


Reply
 
Thread Tools Search this Thread Display Modes
  #1  
Old 05-10-2012
USMLE Forums Addict
 
Steps History: Not yet
Posts: 125
Threads: 50
Thanked 29 Times in 20 Posts
Reputation: 39
Help Phenobarbitone / Gilbert's syndrome relation ?

What is the relation between phenobarbitone and gilbert's syndrome ?

Does it induce jaundice in gilbert's (act as a precipitating factor) or does it cure it ?
Reply With Quote Quick reply to this message



  #2  
Old 05-10-2012
USMLE Forums Master
 
Steps History: 1+CK+CS
Posts: 1,406
Threads: 118
Thanked 642 Times in 407 Posts
Reputation: 652
Default

you mean phenobarbitals?

well Gilberts is a disease that manifests when under stress.
The stress can be infection or drugs.
And ive never heard of a drug that eases Gilberts (in fact, Gilberts is already 'at ease', only manifests when there's stress, as i said above).

So phenobarbitals must induce the symptoms of Gilberts.
__________________
"inflammable means flammable!? What a country."
Reply With Quote Quick reply to this message
  #3  
Old 05-10-2012
DocSikorski's Avatar
USMLE Forums Master
 
Steps History: 1+CK+CS+3
Posts: 1,353
Threads: 94
Thanked 873 Times in 506 Posts
Reputation: 886
Default

Use phenobarbital to treat the symptoms of crigler-najar

Phenobarbital increases UDP glucuronyltransferase production.
Pretty sure it was somewhere in FA
__________________
Ambition is a dream with a V8 engine. EP
Reply With Quote Quick reply to this message
The above post was thanked by:
Dr.NickRiviera (05-10-2012)
  #4  
Old 05-10-2012
USMLE Forums Addict
 
Steps History: Not yet
Posts: 125
Threads: 50
Thanked 29 Times in 20 Posts
Reputation: 39
Default

Quote:
Originally Posted by Dr.NickRiviera View Post
you mean phenobarbitals?

well Gilberts is a disease that manifests when under stress.
The stress can be infection or drugs.
And ive never heard of a drug that eases Gilberts (in fact, Gilberts is already 'at ease', only manifests when there's stress, as i said above).

So phenobarbitals must induce the symptoms of Gilberts.
True, golijan states that jaundice increases with phenobarbital intake
But in wikipedia, it says that in low doses it can reduce its manifestations !
Plus doc sikoriki stating now that FA says it increases glucuronidation

http://74.6.238.254/search/srpcache?ei=UTF-8&p=effect+of+phenobarbitone+on+gilbert%27s&vm=r&f r=yfp-t-742&u=http://cc.bingj.com/cache.aspx?q=effect+of+phenobarbitone+on+gilbert%2 7s&d=4505653202125286&mkt=en-US&setlang=en-US&w=5aeb9c33,55983795&icp=1&.intl=us&sig=URxH.8z_ 6J.q2jfRya8icQ--

see the confusion ?
Reply With Quote Quick reply to this message
  #5  
Old 05-10-2012
USMLE Forums Addict
 
Steps History: Not yet
Posts: 125
Threads: 50
Thanked 29 Times in 20 Posts
Reputation: 39
Default

Quote:
Originally Posted by DocSikorski View Post
Use phenobarbital to treat the symptoms of crigler-najar

Phenobarbital increases UDP glucuronyltransferase production.
Pretty sure it was somewhere in FA

it is pg 333 in the 2011 edition
so now golijan contradicts FA unless i have misunderstood something !
Reply With Quote Quick reply to this message
The above post was thanked by:
DocSikorski (05-10-2012), Dr.NickRiviera (05-10-2012)
  #6  
Old 05-10-2012
USMLE Forums Master
 
Steps History: 1+CK+CS
Posts: 1,039
Threads: 189
Thanked 557 Times in 318 Posts
Reputation: 567
Default ?

Quote:
Originally Posted by hope007 View Post
True, golijan states that jaundice increases with phenobarbital intake
Are you sure Goljan said that about jaundice in Gilbert's syndrome???

I listened to those audios a few days ago and I don't remember him saying anything like that... I double-checked with my notes from the audios and still nothing on what you're saying...do you happen to remember in which audio/section he said that? it'll be easier to trace it.
Reply With Quote Quick reply to this message
  #7  
Old 05-10-2012
USMLE Forums Addict
 
Steps History: Not yet
Posts: 125
Threads: 50
Thanked 29 Times in 20 Posts
Reputation: 39
Default

Quote:
Originally Posted by Casandra View Post
Are you sure Goljan said that about jaundice in Gilbert's syndrome???

I listened to those audios a few days ago and I don't remember him saying anything like that... I double-checked with my notes from the audios and still nothing on what you're saying...do you happen to remember in which audio/section he said that? it'll be easier to trace it.
Not the audios
In his book, it says "jaundice occurs with fasting or increase in alcohol or phenobarbital intake" !
Reply With Quote Quick reply to this message
  #8  
Old 05-10-2012
USMLE Forums Guru
 
Steps History: Step 1 Only
Posts: 452
Threads: 11
Thanked 354 Times in 197 Posts
Reputation: 364
Default

I heard it can be used in the treatment, well that's what it says in dit at least...used for treatment of type 2 criglar nijar and gilberts
Reply With Quote Quick reply to this message
  #9  
Old 05-10-2012
USMLE Forums Master
 
Steps History: 1+CK+CS
Posts: 1,406
Threads: 118
Thanked 642 Times in 407 Posts
Reputation: 652
Default

oh wow, i never saw that before but yea its right there in FA
phenobarbital increases the liver enzymes production and therefore can help in these kinda conditions.

i just learned something new

thanks guys
__________________
"inflammable means flammable!? What a country."
Reply With Quote Quick reply to this message



Reply

Tags
Gastrointestinal-Tract-, Pharmacology-, Physiology-

Quick Reply
Message:
Options

Register Now

In order to be able to post messages on the USMLE Forums forums, you must first register.
Please enter your desired user name, your email address and other required details in the form below.
User Name:
Password
Please enter a password for your user account. Note that passwords are case-sensitive.
Password:
Confirm Password:
Email Address
Please enter a valid email address for yourself.
Email Address:
Medical School
Choose "---" if you don't want to tell. AMG for US & Canadian medical schools. IMG for all other medical schools.
USMLE Steps History
What steps finished! Example: 1+CK+CS+3 = Passed Step 1, Step 2 CK, Step 2 CS, and Step 3.

Choose "---" if you don't want to tell.

Favorite USMLE Books
What USMLE books you really think are useful. Leave blank if you don't want to tell.
Location
Where you live. Leave blank if you don't want to tell.

Log-in

Human Verification

In order to verify that you are a human and not a spam bot, please enter the answer into the following box below based on the instructions contained in the graphic.



Thread Tools Search this Thread
Search this Thread:

Advanced Search
Display Modes


Similar Threads
Thread Thread Starter Forum Replies Last Post
VLDL and HDL Relation! Kabutar111 USMLE Step 1 Forum 2 03-13-2012 04:03 PM
Ventilation relation to PCO2 dr_ace_img USMLE Step 1 Forum 5 02-05-2012 11:12 PM
Ureter relation to Uterine Artery! heman466s USMLE Step 1 Forum 2 11-26-2011 03:21 PM
autism and serotonin relation schiwei USMLE Step 1 Forum 2 12-19-2010 08:49 AM
neurohormonal changes in heart failure and relation to treatment DrSeddik USMLE Step 1 Bits & Pieces 0 02-05-2010 11:06 AM

RSS Feed
Find Us on Facebook
vBulletin Security provided by vBSecurity v2.2.2 (Pro) - vBulletin Mods & Addons Copyright © 2017 DragonByte Technologies Ltd.

USMLE® & other trade marks belong to their respective owners, read full disclaimer
USMLE Forums created under Creative Commons 3.0 License. (2009-2014)