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Old 05-10-2012
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Thyroid pretibial myxedema and exophtalmos question

Graves disease:
Increased synthesis of extracellular matrix (glycosaminglycans, GAG)

Is it basically the same as increasing oncotic pressure in the tissue which pulls the water (transsudate) ?
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No, i think its just the accumulation of these products that leads to eye popping n stuff!
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Originally Posted by vna.rao22 View Post
No, i think its just the accumulation of these products that leads to eye popping n stuff!
What about that one on a leg?

Goljan says its edema
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aha! which lecture is it? Its been ages i listen to them.
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myxedema is the same as edema, just that the increased osmolarity is due to glycosaminoglycans rather than the usual solutes, no?
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myxedema is just a cutaneous and dermal edema due to increase in GAG.GAG increases osmolartiy leading to fluid accumulation ,,,,causing edema....isn't ....
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I thought it was coz of increased amounts of GAG's ... and it looks like edema because they just accumulate and have that edematous consistency ?
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I thought it was coz of increased amounts of GAG's ... and it looks like edema because they just accumulate and have that edematous consistency ?
I also thought that's why it's called myxedema
isn't that right??
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Ok this confirms it:

"The increased deposition of glycosaminoglycans causes an osmotic edema and fluid collection."
(source:http://en.wikipedia.org/wiki/Myxedema)

"Water sticks to GAGs ... The density of sugar molecules and the net negative charges attract cations, for example, Na+, which, after the sodium binds, attracts water molecules."
(source: http://en.wikipedia.org/wiki/Glycosaminoglycans)


And now we know its edema due to osmotic pull & fluid collection due to GAG's deposition!
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Quote:
Originally Posted by Hope2Pass View Post
I thought it was coz of increased amounts of GAG's ... and it looks like edema because they just accumulate and have that edematous consistency ?

I thought the same
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These little things have a big impact on our scores guys, pay attention to crap like that
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Originally Posted by Hope2Pass View Post
Ok this confirms it:

"The increased deposition of glycosaminoglycans causes an osmotic edema and fluid collection."
(source:http://en.wikipedia.org/wiki/Myxedema)
yep, just as i thought
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