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  #1  
Old 05-11-2012
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Skin Diagnosis Of Erythema Multiforme

A 57-year old is refered to a dermatologist for some pale patches, vesicular, or eroded centers with surrounding rings erythematous. The most experimented specialist make the diagnosis of erythema multiforme, which of the following should be present in the immunologic study the to confirm that mannerly?

A) CD8+ cytotoxic cells induces apoptosis by precipitating the infected keratinocytes
B) IgG against epidermal cell surface by inhibition of apoptosis
C) erythema multiforme is not associaciated with infection
D) Estrogen has an inhibitory role in the process of clearing immune complexes
E) It due to deposit IgA at the tips of dermal papilae and treats by: Dapsone





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Old 05-11-2012
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ummmmmmmmm A?
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Old 05-11-2012
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A A A A A A A A A A A........AAAAA
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Old 05-12-2012
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Cell-mediated immunity appears to be responsible for the destruction of epithelial cells. Early in the disease process, the epidermis becomes infiltrated with CD8 T lymphocytes and macrophages, whereas the dermis displays a slight influx of CD4 lymphocytes. These immunologically active cells are not present in sufficient numbers to be directly responsible for epithelial cell death. Instead, they release diffusable cytokines, which mediate the inflammatory reaction and resultant apoptosis of epithelial cells. In some patients, circulating T cells transiently demonstrate (for < 30 d) a T-helper cell type 1 (TH1) cytokine response (interferon [IFN] gamma, tumor necrosis factor [TNF] alpha, interleukin [IL] 2). Results of immunohistochemical analysis have also shown lesion blister fluid to contain TNF, an important proinflammatory cytokine.(c)Medscape
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Quote:
Originally Posted by inno View Post
Cell-mediated immunity appears to be responsible for the destruction of epithelial cells. Early in the disease process, the epidermis becomes infiltrated with CD8 T lymphocytes and macrophages, whereas the dermis displays a slight influx of CD4 lymphocytes. These immunologically active cells are not present in sufficient numbers to be directly responsible for epithelial cell death. Instead, they release diffusable cytokines, which mediate the inflammatory reaction and resultant apoptosis of epithelial cells. In some patients, circulating T cells transiently demonstrate (for < 30 d) a T-helper cell type 1 (TH1) cytokine response (interferon [IFN] gamma, tumor necrosis factor [TNF] alpha, interleukin [IL] 2). Results of immunohistochemical analysis have also shown lesion blister fluid to contain TNF, an important proinflammatory cytokine.(c)Medscape
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Old 05-12-2012
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A is the answer
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Old 08-04-2012
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Default IgM

Isnt erythema multiforme an immune complex deposition, mostly IgM???
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Old 08-04-2012
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I`ll go A

E. multiforme : It`s related with mycoplasma infection and sulfas reaction, I am agree with IgM inmune complex deposition (in the case of mycoplasma "cold aglutinations" ). A cytotoxic (Cd8) response could be posible owing intracelular organism that can be mycoplasma or herpes virus; letter A is related to pemphigus, C and D are false, and E , Ig A in dermal papilaes???
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