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  #1  
Old 05-11-2012
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Question Alzheimer and protein relationship

A 23-year-old boy with a diagnosis of Down syndrome begins to lost his memory visits his counselor, who knows him 5 years ago. A biogenetic study confirms the presence of amyloid core, which of the following the counselor fails to make definitively the diagnosis of a degenerative disease ((Alzheimer disease)?

A) Collagen & APOE4
B) Microtubules & APOE4
C) Collagen & p-App gene
D) Microtubules & p-App gene
E) Microfilaments & p-App gene
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Old 05-11-2012
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i dont really understand the question, so im just going to go with B.
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Quote:
Originally Posted by Dr.NickRiviera View Post
i dont really understand the question, so im just going to go with B.

You are wrong, look in the age if you want to respond correct
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Old 05-11-2012
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oops i mean D.
although im still not sure what the question is asking... lol
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Old 05-11-2012
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Listening

D.........?
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Old 05-11-2012
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Quote:
Originally Posted by Dr.NickRiviera View Post
i dont really understand the question, so im just going to go with B.
Me too but I go for D...
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Old 05-11-2012
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Down Syndrome = trisomy 21 = extra APP gene
So the answer has to be between D or E.
Tau proteins compose neurofibrially tangles ... Tau protein is a microtubular stabilizer ..so the answer is D)

APOE4 = increased risk of Alzheimer's ... it helps in converting alpha amyloid to beta amyloid pleated sheets which can't be broken down and therefore accumulate.

APOE2 = helps in decreasing the risk of Alzheimer's.


Easy question (which is unusual for aljfof's questions lol)...even a person experience disulfiram-like reaction can solve this one

Last edited by Hope2Pass; 05-11-2012 at 10:21 PM.
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Old 05-12-2012
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Quote:
Originally Posted by Hope2Pass View Post
Down Syndrome = trisomy 21 = extra APP gene
So the answer has to be between D or E.
Tau proteins compose neurofibrially tangles ... Tau protein is a microtubular stabilizer ..so the answer is D)

APOE4 = increased risk of Alzheimer's ... it helps in converting alpha amyloid to beta amyloid pleated sheets which can't be broken down and therefore accumulate.

APOE2 = helps in decreasing the risk of Alzheimer's.


Easy question (which is unusual for aljfof's questions lol)...even a person experience disulfiram-like reaction can solve this one

thanks but it asks which one FAILS to make the definitive dx???
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Old 05-12-2012
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I go for D.
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Quote:
Originally Posted by Hope2Pass View Post
Down Syndrome = trisomy 21 = extra APP gene
So the answer has to be between D or E.
Tau proteins compose neurofibrially tangles ... Tau protein is a microtubular stabilizer ..so the answer is D)

APOE4 = increased risk of Alzheimer's ... it helps in converting alpha amyloid to beta amyloid pleated sheets which can't be broken down and therefore accumulate.

APOE2 = helps in decreasing the risk of Alzheimer's.


Easy question (which is unusual for alfjof questions lol)...even a person experience disulfiram-like reaction can solve this one
I like that but is not me is USMLE, I am sorry if I confuse you. I see a lot of question in UW, Kaplan Qbank , and Usmlerx more difficult. I got more question when you are ready let me know to discuss them ok.

The answer is between B or D:
B: Microtubules & APOE4 is present in patient with AD in late age
D: Microtubules & p-APP is present in patient with AD in early age(in this case with trisomy 21)
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Last edited by alfjof; 05-12-2012 at 01:56 PM.
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Quote:
Originally Posted by alfjof View Post
I like that but is not me is USMLE, I am sorry if I confuse you. I see a lot of question in UW, Kaplan Qbank , and Usmlerx more difficult. I got more question when you are ready let me know to discuss them ok
Sure go ahead! Keep posting as many questions as you want .. I just meant that your questions are challenging!
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Originally Posted by Hope2Pass View Post
Sure go ahead! Keep posting as many questions as you want .. I just meant that your questions are challenging!
No problem you are welcome, and I got more than 10 for this weekend
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