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Old 05-13-2012
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Biochemistry NADPH Oxidase and Atherosclerosis!

Are both NADPH oxidase and Myeloperoxidase normally absent in Macrophages? Or is it just Myeloperoxidase that's absent?

And if someone could someone plz explain how NADPH oxidase can cause atherosclerosis, it'd be awesome.

Thanks
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Old 05-13-2012
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in respiratory burst which is actualy the production of HOCL(bleach)
1)NADPH oxidase converts oxygen to superoxide
2)superoxide dismutase converts superoxide to hydrogen peroxide
3)myeloperoxidase then produce hydrogen chloride ie bleach which do the actual killing

so to your first question,
these enzymes have to be present for macrophage oxygen dependent killing but not needed in oxygen independent killing which uses phagolysosomes.
NADPH oxydase def & SOD def cause CGD(chronic granulomatous dx with neutropenia ,recurrent inf,albinism,peripheral neuropathy,undetached umbilical cord etc) while def of myeloperoxidase cause recurrent candida infection only.

to ur 2nd question
NADPH oxidase generates free oxygen radicals which by lipid peroxidation(via free radical injury) damage vascular collagen layer which acts as nidus for atherosclerosis.

hope this helps.
sorry for the long explanation;just testing my memory recall
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Old 05-13-2012
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Thanks, but I was sure Myeloperoxidase is only found in Neutrophils and monocytes and not macrophages. Not sure if it was the same for NADPH oxidase. Based on ur reply, if i understood it correctly, it'd mean that macrophages do have both enzymes but only use it in oxidant dependent killing?
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Old 05-14-2012
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thats my point.there is myeloperoxidase in macrophages (monocytes in blood diffrentiated to macrophages tissues)
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