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Old 05-14-2012
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Liver Bilirubin Question(UW)

If energy-dependent organic anion transport across the hepatocellular membrane is selectively inhibited, which of the following would most likely result?

A. decreased haptoglobin concentration in the serum
B. increased urobilinogen absorption in the gut
C. increased bilirubin excretion in the urine
D. increased indirect bilirubin uptake from the blood
E. increased stecrobilin excretion in the feces

please exlpain too!
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Old 05-14-2012
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answer is C

bilirubin uptake is passive, but it's excretion from the liver is energy dependent... if this energy dependant proccess is lost... somthing like "dubin johnson" syndrome results,,, where bilirubin accumulates in the liver.. and some of it spills into the blood....
notice that this thing that is spilled back into the blood is CONJUGATED [nothing wrong with the enzymes responsible for this conjugation].. so its water soluble and less protien bound than the uncounguagted form... so this water soluble substance is also excreted in the urine
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Old 05-14-2012
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C? Im not sure though
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Old 05-14-2012
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yeah....answer would be C) definitely
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I agree it is choice C.... but a really easy/ simple way to think about it is.... if I can't get bilirubin into my bile duct ...which of the following will happen?... this is similar to obstructive jaundice (in your bile ducts) with a lot of bilirubin in your urine but non in your stool ("clay colored stool")
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