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  #1  
Old 05-24-2010
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Blood Lymphoma Translocation!

A patient with a lymphoma has an involved lymph node resected and examined pathologically. The lymph node shows a malignant proliferation of small cleaved cells that are most prominent in the areas immediately outside the follicles. Immunohistochemical stains show the cells are positive for CD19, CD20, and CD5 but are negative for CD23. This type of lymphoma is associated with a characteristic translocation that involves which of the following?

(A) bcl-1 and immunoglobulin heavy-chain gene
(B) bcl-2 and immunoglobulin heavy-chain gene
(C) c-abl and bcr
(D) c-myc and immunoglobulin heavy-chain gene
(E) PML and RAR-alpha
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  #2  
Old 05-24-2010
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Idea! is that follicular lymphoma(B cell lymphoma) ?

(B) bcl-2 and immunoglobulin heavy-chain gene, i think is answer !
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  #3  
Old 05-24-2010
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Default A is correct

that s small lymphocytic lymphoma (very similar to CLL).The correct answer is A.

Bcl2 is for follicular lymphoma
c-abl and bcr is for CML
Cmyc for burkitt lymphoma
PML and RAR-alpha for acute promyelocytic leukemia
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  #4  
Old 05-24-2010
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Default A

(A) bcl-1 and immunoglobulin heavy-chain gene
its a mantle cell lymphoma. This tumor arises from the mantle zone B lymphocytes, and the tumor cells are positive for CD19, CD20, and CD5
and negative for CD23. Translocation t(11;14) is characteristic.
Chromosome 11 has bcl-1, and chromosome 14 has immunoglobulin heavy-chain genes.
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The above post was thanked by:
m82_ghasemi (09-09-2011)



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