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  #1  
Old 05-15-2012
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Bacteria Mechanism of Resistance to Rifampin

In a woman from Asia with TB you decide to go with rifampin as treatment, by which of the following mechanism the patient should resist to rifampin?


A) Delays resistance in dapsone if it use for leprosy
B) Inhibits DNA-dependent RNA polymerase
C) RNA polymerase inhibitor revs up microsomal P-450
D) Alteration of structure of enzymes involves in RNA synthesis
E) Minor hepatotoxicity and drug interactions




It is not me the fault is for the board!!!!!!!!11
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Old 05-15-2012
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I'm guessing the question is asking for the method of resistance to Rifampin ... I'd go with D) Alteration of structure of enzymes involves in RNA synthesis...Altered RNA Polymerase could lead to resistance. The mechanism of action of Rifampin is C) RNA polymerase inhibitor revs up microsomal P-450.


Remember the R's of Rifampin-

-RNA Polymerase Inhibitor
-Revs up P450
-Red/Orange body fluids
-Rapid Resistance if used alone.


Man, no offense, your questions are good but poorly worded! It's hard to understand sometimes what the question is asking lol
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Originally Posted by Hope2Pass View Post
I'm guessing the question is asking for the method of resistance to Rifampin ... I'd go with D) Alteration of structure of enzymes involves in RNA synthesis...Altered RNA Polymerase could lead to resistance. The mechanism of action of Rifampin is C) RNA polymerase inhibitor revs up microsomal P-450.


Remember the R's of Rifampin-

-RNA Polymerase Inhibitor
-Revs up P450
-Red/Orange body fluids
-Rapid Resistance if used alone.


Man, no offense, your questions are good but poorly worded! It's hard to understand sometimes what the question is asking lol


You will see a lot of questions like that on your real test I want all of this forum and you anderstand that, and the question is clear: Mechanism of resistance of Rifampin
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D) Alteration of structure of enzymes involves in RNA synthesis

Altering the core enzyme (I think B' subunit?) so that rifampin cannot bind/inhibit.
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Says D too..
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D i suppose
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I'm afraid to answer (My self-esteem and self-confidence are in jeopardy)... but I go for D
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Quote:
Originally Posted by Hope2Pass View Post
Remember the R's of Rifampin-

-RNA Polymerase Inhibitor
-Revs up P450
-Red/Orange body fluids
-Rapid Resistance if used alone.
This is good stuff~~~
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Old 05-16-2012
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i wanna tell you that i got the same Q in the exam yesterday, but it was '' how the mutation to RNA polymerase occured? ''
missense, nonsense, frameshift, insertion, deletion
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Originally Posted by the white eagle View Post
i wanna tell you that i got the same Q in the exam yesterday, but it was '' how the mutation to RNA polymerase occured? ''
missense, nonsense, frameshift, insertion, deletion

I always tell them in this forum all question I posted they can find them in the real exam, sometime they fight with me or tell me they are poor word or they not anderstand what the question ask him
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Old 05-16-2012
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I agree with you totally, despite that they are not to much in the exam...but i think knowing those details can push your score a little up
keep on
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Quote:
Originally Posted by the white eagle View Post
i wanna tell you that i got the same Q in the exam yesterday, but it was '' how the mutation to RNA polymerase occured? ''
missense, nonsense, frameshift, insertion, deletion
what is the answer ?
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Old 05-16-2012
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Default Explanation

A) Delays resistance in dapsone if it use for leprosy
B) Inhibits DNA-dependent RNA polymerase
C) RNA polymerase inhibitor revs up microsomal P-450
D) Alteration of structure of enzymes involves in RNA synthesis: Correct answer
E) Minor hepatotoxicity and drug interactions

A-B-C-E: are other mechanism of action of rifampim but not the mechanism of resistance
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