Which Ultraviolet Ligth Hurting Xeroderma Pigmentosum Skin! - USMLE Forums
USMLE Forums Logo
USMLE Forums         Your Reliable USMLE Online Community     Members     Posts
Home
USMLE Articles
USMLE News
USMLE Polls
USMLE Books
USMLE Apps
Go Back   USMLE Forums > USMLE Step 1 Forum

USMLE Step 1 Forum USMLE Step 1 Discussion Forum: Let's talk about anything related to USMLE Step 1 exam


Reply
 
Thread Tools Search this Thread Display Modes
  #1  
Old 05-15-2012
alfjof's Avatar
USMLE Forums Veteran
 
Steps History: Step 1 Only
Posts: 251
Threads: 56
Thanked 105 Times in 63 Posts
Reputation: 115
Send a message via Yahoo to alfjof
DNA Which Ultraviolet Ligth Hurting Xeroderma Pigmentosum Skin!

A 15-year-old girl has been finding a defect in the repair enzyme DNA polymerase DNA ligase by AP endonuclease. Which of the following will be most likely damaging the skin of this patient?

A) UV-A or UV-C
B) UV-D or UV-E
C) UV-B or UV-C
D) UV-E or UV-B
E) UV-B or UV-A
F) UV-A or UV-D

It was on my real......... you can imagine, and I was in this day
__________________
Happy to Learn New Concept and Mechanism each Day

Last edited by alfjof; 05-15-2012 at 08:36 PM.
Reply With Quote Quick reply to this message
The above post was thanked by:
Linc (10-13-2015), researchmedicine (05-17-2012)



  #2  
Old 05-15-2012
Hope2Pass's Avatar
USMLE Forums Master
 
Steps History: 1+CK+CS+3
Posts: 1,684
Threads: 213
Thanked 1,600 Times in 660 Posts
Reputation: 1610
Default

C.........?
Reply With Quote Quick reply to this message
  #3  
Old 05-15-2012
USMLE Forums Master
 
Steps History: ---
Posts: 530
Threads: 35
Thanked 291 Times in 207 Posts
Reputation: 301
Default

i go for C aswell.
__________________
Life is a sexually transmitted disease.
Reply With Quote Quick reply to this message
 
  #4  
Old 05-15-2012
USMLE Forums Master
 
Steps History: Not yet
Posts: 590
Threads: 8
Thanked 239 Times in 192 Posts
Reputation: 249
Default

Waw!! Thanks for telling us it was on the real exam.. I was js thinking "wtf.. I dono :S May be I should skip it.." lol!

C????
Reply With Quote Quick reply to this message
  #5  
Old 05-15-2012
USMLE Forums Addict
 
Steps History: Not yet
Posts: 135
Threads: 3
Thanked 73 Times in 48 Posts
Reputation: 83
Default

E) UV-B or UV-A

Quote:
A 15-year-old girl has been finding a defect in the repair enzyme DNA polymerase DNA ligase by AP endonuclease. Which of the following will be most likely dammage the skin of this patient?
I thought only uvrABC excinucleases are involved in XP, what's AP endonuclease doing in the stem?
__________________

To view links or images in signatures your post count must be 10 or greater. You currently have 0 posts.
You can't confuse the confused!
To view links or images in signatures your post count must be 10 or greater. You currently have 0 posts.
Reply With Quote Quick reply to this message
  #6  
Old 05-16-2012
Relid's Avatar
USMLE Forums Scout
 
Steps History: ---
Posts: 57
Threads: 8
Thanked 31 Times in 19 Posts
Reputation: 41
Default

I believe that you may not remember the question...

Was it asking you which genes are involved in XP? Answer being XPA and XPC genes...
Reply With Quote Quick reply to this message
  #7  
Old 05-16-2012
imgchuchu's Avatar
USMLE Forums Veteran
 
Steps History: Not yet
Posts: 218
Threads: 4
Thanked 74 Times in 55 Posts
Reputation: 84
Default

this is def of excision endonucleases which repairs thymine dimers caused by UV A,B and C
Reply With Quote Quick reply to this message
  #8  
Old 05-16-2012
imgchuchu's Avatar
USMLE Forums Veteran
 
Steps History: Not yet
Posts: 218
Threads: 4
Thanked 74 Times in 55 Posts
Reputation: 84
Default

Now i got it
UV A,B & C are emitted from the sun but uv C does not cross the ozone layer

so option E





thanx for the question dude
Reply With Quote Quick reply to this message
  #9  
Old 05-16-2012
alfjof's Avatar
USMLE Forums Veteran
 
Steps History: Step 1 Only
Posts: 251
Threads: 56
Thanked 105 Times in 63 Posts
Reputation: 115
Send a message via Yahoo to alfjof
Default

Quote:
Originally Posted by Relid View Post
I believe that you may not remember the question...

Was it asking you which genes are involved in XP? Answer being XPA and XPC genes...

I remember all hard questions they frustrated me, it was like that papa. Other thing, they can give you the Dx with all definition and lack the answer ok
__________________
Happy to Learn New Concept and Mechanism each Day
Reply With Quote Quick reply to this message
  #10  
Old 05-16-2012
USMLE Forums Addict
 
Steps History: Not yet
Posts: 135
Threads: 3
Thanked 73 Times in 48 Posts
Reputation: 83
Default

Interesting question, looking forward to the answer and explanation.
__________________

To view links or images in signatures your post count must be 10 or greater. You currently have 0 posts.
You can't confuse the confused!
To view links or images in signatures your post count must be 10 or greater. You currently have 0 posts.
Reply With Quote Quick reply to this message
  #11  
Old 05-16-2012
Dr. Mexito's Avatar
USMLE Forums Master
 
Steps History: 1+CK+CS
Posts: 662
Threads: 72
Thanked 370 Times in 204 Posts
Reputation: 380
Default

I think is

UV-B UV-A

That's why new sun blocker now also cover UV-A
__________________
"Disease is very old, and nothing about it has changed. It is we who change as we learn to recognize what was formerly imperceptible." JMC
Reply With Quote Quick reply to this message
  #12  
Old 05-16-2012
USMLE Forums Guru
 
Steps History: 1+CK+CS+3
Posts: 457
Threads: 62
Thanked 276 Times in 186 Posts
Reputation: 286
Default

looks like E
Reply With Quote Quick reply to this message
  #13  
Old 05-16-2012
DocSikorski's Avatar
USMLE Forums Master
 
Steps History: 1+CK+CS+3
Posts: 1,353
Threads: 94
Thanked 877 Times in 507 Posts
Reputation: 890
Default

Wow!
I sent this question to my PhD collegue... she was working with UV radiation and polimerases... lets what she says
__________________
Ambition is a dream with a V8 engine. EP
Reply With Quote Quick reply to this message
  #14  
Old 05-16-2012
alfjof's Avatar
USMLE Forums Veteran
 
Steps History: Step 1 Only
Posts: 251
Threads: 56
Thanked 105 Times in 63 Posts
Reputation: 115
Send a message via Yahoo to alfjof
Default Explanation

E) UV-B or UV-A: Correct answer and UV-C not represent a danger for px with xeroderma pigmentosum.



I found the answer after I left the examen room online after 3hrs, neither Kaplan, UW, and USMLERx get this one waoh!!!
__________________
Happy to Learn New Concept and Mechanism each Day
Reply With Quote Quick reply to this message
  #15  
Old 05-16-2012
USMLE Forums Guru
 
Steps History: 1+CK+CS+3
Posts: 457
Threads: 62
Thanked 276 Times in 186 Posts
Reputation: 286
Default

never seen it. i just thought of all those sun screen lotion advertisement n they all say that protect from B n A types :-0 :-0
Quote:
Originally Posted by alfjof View Post
E) UV-B or UV-A: Correct answer and UV-C not represent a danger for px with xeroderma pigmentosum.



I found the answer after I left the examen room online after 3hrs, neither Kaplan, UW, and USMLERx get this one waoh!!!
Reply With Quote Quick reply to this message



  #16  
Old 05-16-2012
USMLE Forums Master
 
Steps History: 1+CK+CS
Posts: 1,406
Threads: 118
Thanked 647 Times in 409 Posts
Reputation: 657
Default

experimental question... lol
__________________
"inflammable means flammable!? What a country."
Reply With Quote Quick reply to this message
  #17  
Old 05-16-2012
alfjof's Avatar
USMLE Forums Veteran
 
Steps History: Step 1 Only
Posts: 251
Threads: 56
Thanked 105 Times in 63 Posts
Reputation: 115
Send a message via Yahoo to alfjof
Default

Quote:
Originally Posted by Dr.NickRiviera View Post
experimental question... lol

I believe no
__________________
Happy to Learn New Concept and Mechanism each Day
Reply With Quote Quick reply to this message
  #18  
Old 05-16-2012
Dr. Mexito's Avatar
USMLE Forums Master
 
Steps History: 1+CK+CS
Posts: 662
Threads: 72
Thanked 370 Times in 204 Posts
Reputation: 380
Default

Quote:
Originally Posted by alfjof View Post
E) UV-B or UV-A: Correct answer and UV-C not represent a danger for px with xeroderma pigmentosum.



I found the answer after I left the examen room online after 3hrs, neither Kaplan, UW, and USMLERx get this one waoh!!!
This one is in UW... I mean... they don't specifically ask bout this but they mention AV-B and AV-A radiation... That's how I got it right..
__________________
"Disease is very old, and nothing about it has changed. It is we who change as we learn to recognize what was formerly imperceptible." JMC
Reply With Quote Quick reply to this message
  #19  
Old 05-16-2012
DocSikorski's Avatar
USMLE Forums Master
 
Steps History: 1+CK+CS+3
Posts: 1,353
Threads: 94
Thanked 877 Times in 507 Posts
Reputation: 890
Default

Quote:
Originally Posted by DocSikorski View Post
Wow!
I sent this question to my PhD collegue... she was working with UV radiation and polimerases... lets what she says
She never answered, but my Ray Ban sunglassess guarantee 100% UVA and UVB protection...
__________________
Ambition is a dream with a V8 engine. EP
Reply With Quote Quick reply to this message
  #20  
Old 05-16-2012
alfjof's Avatar
USMLE Forums Veteran
 
Steps History: Step 1 Only
Posts: 251
Threads: 56
Thanked 105 Times in 63 Posts
Reputation: 115
Send a message via Yahoo to alfjof
Default

Quote:
Originally Posted by DocSikorski View Post
She never answered, but my Ray Ban sunglassess guarantee 100% UVA and UVB protection...


Lol! are you ready for the next questions today?
__________________
Happy to Learn New Concept and Mechanism each Day
Reply With Quote Quick reply to this message
  #21  
Old 05-16-2012
DocSikorski's Avatar
USMLE Forums Master
 
Steps History: 1+CK+CS+3
Posts: 1,353
Threads: 94
Thanked 877 Times in 507 Posts
Reputation: 890
Default

Quote:
Originally Posted by alfjof View Post
Lol! are you ready for the next questions today?
always!!
__________________
Ambition is a dream with a V8 engine. EP
Reply With Quote Quick reply to this message
  #22  
Old 05-16-2012
DocSikorski's Avatar
USMLE Forums Master
 
Steps History: 1+CK+CS+3
Posts: 1,353
Threads: 94
Thanked 877 Times in 507 Posts
Reputation: 890
Default

hey guys, so here is what an a PhD student says on it. She works with polymerases and DNA repair and uses UV light frequently to damage DNA in yiest and fungi.

UVA will not damage DNA. Its wave length is not enough to be absorbed by DNA.

UVC would make a major damage to DNA, but its stopped by ozone layer.
But in the question we have "damage skin" so if ozone layer protects - than UVC is excluded...
But UVB can possibly act on the skin through free radicals formation!!!

Crazy arse shiet!
I trust her and Ray Bans - answer - UVB and UVA
====================


I wish my PhD friends, Goljan and my dog could go with me to the exam...
__________________
Ambition is a dream with a V8 engine. EP
Reply With Quote Quick reply to this message
  #23  
Old 05-16-2012
USMLE Forums Master
 
Steps History: Not yet
Posts: 590
Threads: 8
Thanked 239 Times in 192 Posts
Reputation: 249
Default

Quote:
Originally Posted by DocSikorski View Post
hey guys, so here is what an a PhD student says on it. She works with polymerases and DNA repair and uses UV light frequently to damage DNA in yiest and fungi.

UVA will not damage DNA. Its wave length is not enough to be absorbed by DNA.

UVC would make a major damage to DNA, but its stopped by ozone layer.
But in the question we have "damage skin" so if ozone layer protects - than UVC is excluded...
But UVB can possibly act on the skin through free radicals formation!!!

Crazy arse shiet!
I trust her and Ray Bans - answer - UVB and UVA
====================


I wish my PhD friends, Goljan and my dog could go with me to the exam...
Thanks for sharing your PhD friend's explanation...
LOl @ "I wish my PhD friends, Goljan and my dog could go with me to the exam..."
Reply With Quote Quick reply to this message



Reply

Tags
Molecular-Biology-, Pathology-, Skin-, Step-1-Questions

Quick Reply
Message:
Options

Register Now

In order to be able to post messages on the USMLE Forums forums, you must first register.
Please enter your desired user name, your email address and other required details in the form below.
User Name:
Password
Please enter a password for your user account. Note that passwords are case-sensitive.
Password:
Confirm Password:
Email Address
Please enter a valid email address for yourself.
Email Address:
Medical School
Choose "---" if you don't want to tell. AMG for US & Canadian medical schools. IMG for all other medical schools.
USMLE Steps History
What steps finished! Example: 1+CK+CS+3 = Passed Step 1, Step 2 CK, Step 2 CS, and Step 3.

Choose "---" if you don't want to tell.

Favorite USMLE Books
What USMLE books you really think are useful. Leave blank if you don't want to tell.
Location
Where you live. Leave blank if you don't want to tell.

Log-in

Human Verification

In order to verify that you are a human and not a spam bot, please enter the answer into the following box below based on the instructions contained in the graphic.



Thread Tools Search this Thread
Search this Thread:

Advanced Search
Display Modes


Similar Threads
Thread Thread Starter Forum Replies Last Post
poor uw scores hurting my confidence ispy USMLE Step 1 Forum 1 11-04-2016 02:40 PM
skin pigmentation ricko335 USMLE Step 1 Forum 5 06-21-2012 09:42 AM
Free 150 and NBME Scores Hurting my Confidence ispy USMLE Step 2 CK Forum 7 05-03-2012 04:04 PM
Skin ca scopusmount USMLE Step 1 Forum 4 01-19-2012 11:00 AM
skin disease khushboo USMLE Step 1 Forum 7 05-23-2010 11:40 AM

RSS Feed
Find Us on Facebook
vBulletin Security provided by vBSecurity v2.2.2 (Pro) - vBulletin Mods & Addons Copyright © 2017 DragonByte Technologies Ltd.

USMLE® & other trade marks belong to their respective owners, read full disclaimer
USMLE Forums created under Creative Commons 3.0 License. (2009-2014)