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Old 05-16-2012
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Liver Primary biliary cirrhosis and jaundice

I was reading where primary biliary cirrhosis usually presents with intense itching without jaundice. The itching makes sense since the bilirubin is elevated, but why wouldn't there be jaundice too?
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Old 05-16-2012
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There would be jaundice too... but it appears rather late.... so, most of the patients when present to you, they come with pruritus...
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Old 05-16-2012
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Quote:
Originally Posted by lsumed64 View Post
I was reading where primary biliary cirrhosis usually presents with intense itching without jaundice. The itching makes sense since the bilirubin is elevated, but why wouldn't there be jaundice too? Thanks!
Goljan RR says , 60% of patient will present with Jaundice. But its a late finding after bile ducts have been destroyed.

By the way Pruritis (itching ) is mostly of unknown etiology and is found in early stage.and could be bcos of no bile salts in skin.

??????????????
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Ahh I see. Makes much more sense now. Thanks. About the pruritis- I think I remember a path teacher in school talking about how the itching likely comes from the build up of bilirubin in the skin (or maybe it's just irritating to the nerves???).
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Well, Golijan specifically mentions the itch is not due to bilirubin in the skin... Dont know if thats important...
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You're right, likely not important. But I'll go with what you and Goljan are saying.
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