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Old 05-16-2012
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Skin Psoriasis & Cytokines Association

A 38-year-old female presents to your office over his elbows and knees bilaterally. Biopsy of the lesions shows a prominent parakeratotic stratum corneum with focal of neutrophil accumulation. If diagnosis of psoriasis is possible in this patient, which of the following cytokines should establish the finale diagnosis?


A) IFN-γ, TNF-α, and TNF-β
B) Lytic enzymes, TNF, and perforin
C) IFN-α, IFN-β, and IL-12
D) TNF, IL-12, and IFN-γ
E) TNF-α, IFN-γ, and IL-1
F) IFN-γ, IL-2, and TNF-β
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  #2  
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Is F the answer?
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Quote:
Originally Posted by alfjof View Post
A 38-year-old female presents to your office with a rash over his elbows and knees bilaterally. Biopsy of the lesions shows a prominent parakeratotic stratum corneum with focal of neutrophil accumulation. If diagnosis of psoriasis is possible in this patient, which of the following cytokines should establish the finale diagnosis?


A) IFN-γ, TNF-α, and TNF-β
B) Lytic enzymes, TNF, and perforin
C) IFN-α, IFN-β, and IL-12
D) TNF, IL-12, and IFN-γ
E) TNF-α, IFN-γ, and IL-1
F) IFN-γ, IL-2, and TNF-β

Sorry for forgetting to Put With A Rash
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  #4  
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Quote:
Originally Posted by alfjof View Post
A 38-year-old female presents to your office over his elbows and knees bilaterally. Biopsy of the lesions shows a prominent parakeratotic stratum corneum with focal of neutrophil accumulation. If diagnosis of psoriasis is possible in this patient, which of the following cytokines should establish the finale diagnosis?


A) IFN-γ, TNF-α, and TNF-β
B) Lytic enzymes, TNF, and perforin
C) IFN-α, IFN-β, and IL-12
D) TNF, IL-12, and IFN-γ
E) TNF-α, IFN-γ, and IL-1
F) IFN-γ, IL-2, and TNF-β
I will go with D.
@alfjof - Are you sure that it says TNF only and not TNF-alpha?
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Originally Posted by Casandra View Post
I will go with D.
@alfjof - Are you sure that it says TNF only and not TNF-alpha?

Yes!!!!!!!!!!
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Originally Posted by alfjof View Post
Yes!!!!!!!!!!
then I think there's something wrong with the given answers.
Psoriasis is characterized by Th1-type cytokine pattern with predominant secretion of IL-2, IL-6, IFN-alpha, TNF-alpha. Studies also proved a correlation between psoriasis and IL-8, IL-10, IL-12 levels.

Where is this question from?
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  #7  
Old 05-17-2012
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Where is this question from?[/QUOTE]



I can't tell you where this question from
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have no idea about this , but would go with c
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Quote:
Originally Posted by Casandra View Post
then I think there's something wrong with the given answers.
Psoriasis is characterized by Th1-type cytokine pattern with predominant secretion of IL-2, IL-6, IFN-alpha, TNF-alpha. Studies also proved a correlation between psoriasis and IL-8, IL-10, IL-12 levels.

Where is this question from?


where u got this info from , I ve never heard it before??
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where u got this info from , I ve never heard it before??

In Kaplan Video Immunology you have all of them
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  #11  
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Originally Posted by alfjof View Post
In Kaplan Video Immunology you have all of them

is that only in video or in text book as well???
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  #12  
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is that only in video or in text book as well???

I don't see it in the text book, remember to take note when you are doing all KPL Video
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  #13  
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Originally Posted by alfjof View Post

I can't tell you where this question from
really?? what's with all this secrecy?
everyone on this forum, when asked, always gives the source of their question
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  #14  
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where u got this info from , I ve never heard it before??
I have been taught that in my dermatology rotation.
here's one of the online resources you can refer to on that:

http://books.google.pl/books?id=9-Ra...page&q&f=false

I have watched Kaplan Immunology videos and those cytokines are mentioned there (their functions etc.) but I don't recall, as alfjof says, those cytokines to be talked about in terms of psoriasis. If I am wrong, please let me know which videos refer to psoriasis.
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  #15  
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Quote:
Originally Posted by alfjof View Post
In Kaplan Video Immunology you have all of them
In which video(s) do they talk about the cytokines in psoriasis?
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Quote:
Originally Posted by Casandra View Post
I have been taught that in my dermatology rotation.
here's one of the online resources you can refer to on that:

http://books.google.pl/books?id=9-Ra...page&q&f=false

I have watched Kaplan Immunology videos and those cytokines are mentioned there (their functions etc.) but I don't recall, as alfjof says, those cytokines to be talked about in terms of psoriasis. If I am wrong, please let me know which videos refer to psoriasis.


thanks alot , I know these cytokines ,and their functions , although did not watch all immunology videos , but what I meant is their relation to psoriasis , which I have no idea about

thanks alot for the link
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  #17  
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Originally Posted by mycoplasma View Post
thanks alot , I know these cytokines ,and their functions , although did not watch all immunology videos , but what I meant is their relation to psoriasis , which I have no idea about

thanks alot for the link
I totally get your point.. I don't remember anything in specific about cytokines and psoriasis coming from KLN (either in the videos or in the notes). I remembered that from my dermatology rotation only. But since alfjof said it's there I hope he/she will be able to point out where exactly in Kaplan materials it can be found After all, this forum is all about exchanging the ideas and sharing knowledge
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Quote:
Originally Posted by Casandra View Post
I totally get your point.. I don't remember anything in specific about cytokines and psoriasis coming from KLN (either in the videos or in the notes). I remembered that from my dermatology rotation only. But since alfjof said it's there I hope he/she will be able to point out where exactly in Kaplan materials it can be found After all, this forum is all about exchanging the ideas and sharing knowledge

Sorry to tell you that: there is a privacity rule in this forum, again I can tell you where this question from ok
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Originally Posted by alfjof View Post
Sorry to tell you that: there is a privacity rule in this forum, again I can tell you where this question from ok
There's a privacy rule in this forum about what? The source of the questions?

really??


Since you said you could tell where was this question from, without further ado, just say it
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  #20  
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Default Explanation

A) IFN-γ, TNF-α, and TNF-β: Products of mechanism of killing(CTLs)
B) Lytic enzymes, TNF, and perforin: Antibody Dependent Cell-Mediated Cytotoxicity(ADCC)
C) IFN-α, IFN-β, and IL-12: NK
D) TNF, IL-12, and IFN-γ: Psoriasis(UWorld reference)[Correct answer]
E) TNF-α, IFN-γ, and IL-1: Products of Cachexia in cancer
F) IFN-γ, IL-2, and TNF-β: Stimulates effector cells of CMI(TH1)
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  #21  
Old 05-17-2012
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Originally Posted by Casandra View Post
There's a privacy rule in this forum about what? The source of the questions?
really??
Since you said you could tell where was this question from, without further ado, just say it
I agree with Casandra! I'd like to know where you get these questions and their answers from. As long as they are not NBME questions, you can share the source! (book, qbank, online link, anything is fine!)
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Originally Posted by Hope2Pass View Post
I agree with Casandra! I'd like to know where you get these questions and their answers from. As long as they are not NBME questions, you can share the source! (book, qbank, online link, anything is fine!)
alfjof already mentioned the source above.. Read it again
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  #23  
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Originally Posted by sukar View Post
alfjof already mentioned the source above.. Read it again
unfortunately no those cytokines are mentioned in Kaplan videos but NOT in the reference to psoriasis. So it's not a source of this question
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  #24  
Old 05-18-2012
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"D) TNF, IL-12, and IFN-γ: Psoriasis(UWorld reference)[Correct answer]"

Source doesn't seem like kaplan
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  #25  
Old 05-18-2012
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Default Source!!!!!!!!

Quote:
Originally Posted by sukar View Post
"D) TNF, IL-12, and IFN-γ: Psoriasis(UWorld reference)[Correct answer]"

Source doesn't seem like kaplan


UW Qid: 78247 2nd paragraph: Psoriasis appears to cause by CD4+ cells that activate CD8+ T-cells in the epithelium after interacting with antigen-presenting cells in the skin. The interaction between these 2 cells, the dendritic cells and the neighboring keratinocytes result in the production of cytokines: TNF, IL-12, IFN-γ, and keratinocytes growth factors. In reponse, keratinocyte proliferation, inflammation, and angiogenesis occur. The only thing UW forget to mentionate in the beautiful explanation is TNF-alpha and I find it in another way

So, everything is clear now
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  #26  
Old 05-18-2012
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Quote:
Originally Posted by Casandra View Post
unfortunately no those cytokines are mentioned in Kaplan videos but NOT in the reference to psoriasis. So it's not a source of this question

Stop! I give you the source, now I need to see and ok
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