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  #1  
Old 05-16-2012
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GIT Ulcerative Colitis & Cytokines Association

A 27-year old female with sclerosing cholangitis presents to your office with one year history of lost stools and abdominal pain; tells you that: Her aunt had ulcerative colitis and her grand-father died of colon cancer at age of 55 years. A biopsy of the colon shows mucosa and submucosa inflammation and pyoderma gengrenosum. Association of which of the cytokines would be a major factor in the development of this disease?


A) IL-4, IL-5, IL-6, and IL-10
B) TH1, IL-2, IFN-γ, and TNF
C) IL-1, IL-6, IL-8, and NO
D) IL-4, IL-7, IL-9, and IL-15
E) IFN-α, IFN-β, and IL-12


All questions I posted in this forum that one I like it more and
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Last edited by alfjof; 05-16-2012 at 08:21 PM.
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Old 05-16-2012
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A 27-year old female with sclerosing cholangitis presents to your office with one year history of lost stools and abdominal pain; tells you that: Her aunt had ulcerative colitis and her grand-father died of colon cancer at age of 55 years. A biopsy of the colon shows mucosa and submucosa inflammation and pyoderma gengrenosum. Association of which of the cytokines would be a major factor in the development of this disease?


A) IL-4, IL-5, IL-6, and IL-10
B) TH1, IL-2, IFN-γ, and TNF
C) IL-1, IL-6, IL-8, and NO
D) IL-4, IL-7, IL-9, and IL-15
E) IFN-α, IFN-β, and IL-12

i think B but TH1 means t helper 1 right?
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Old 05-16-2012
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B.

CMI involvement
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  #4  
Old 05-16-2012
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Quote:
Originally Posted by beka-CTS View Post
A 27-year old female with sclerosing cholangitis presents to your office with one year history of lost stools and abdominal pain; tells you that: Her aunt had ulcerative colitis and her grand-father died of colon cancer at age of 55 years. A biopsy of the colon shows mucosa and submucosa inflammation and pyoderma gengrenosum. Association of which of the cytokines would be a major factor in the development of this disease?


A) IL-4, IL-5, IL-6, and IL-10
B) TH1, IL-2, IFN-γ, and TNF
C) IL-1, IL-6, IL-8, and NO
D) IL-4, IL-7, IL-9, and IL-15
E) IFN-α, IFN-β, and IL-12

i think B but TH1 means t helper 1 right?
Yeah it does

I go with B also, HLA-b27 is a MHC-1...so interacts with cd 4...ala Il-2 and IFN Gamma stimulated from th1 cells....and Ifn gamma stimulates macrophages which in turn releases your acute phase reactants like TNF
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Old 05-16-2012
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Quote:
Originally Posted by alfjof View Post
A 27-year old female with sclerosing cholangitis presents to your office with one year history of lost stools and abdominal pain; tells you that: Her aunt had ulcerative colitis and her grand-father died of colon cancer at age of 55 years. A biopsy of the colon shows mucosa and submucosa inflammation and pyoderma gengrenosum. Association of which of the cytokines would be a major factor in the development of this disease?


A) IL-4, IL-5, IL-6, and IL-10
B) TH1, IL-2, IFN-γ, and TNF
C) IL-1, IL-6, IL-8, and NO
D) IL-4, IL-7, IL-9, and IL-15
E) IFN-α, IFN-β, and IL-12
I'd go with B too.

Quote:
Originally Posted by alfjof View Post
All questions I posted in this forum that one I like it more and
Could you please re-write/elaborate what your last sentence means?
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  #6  
Old 05-16-2012
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Quote:
Originally Posted by Casandra View Post
I'd go with B too.



Could you please re-write/elaborate what your last sentence means?

Nothing serious!!!!!!!!!!!!!!
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Old 05-17-2012
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Answer is A

Ulcerative colitis is ----- Th2 mediated, not Th1 !!!! So ----- IL4 and IL5 induce growth of B cells, IL10 inflammatory response.
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Old 05-17-2012
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A should be the answer/. Th1 is associated with Crohn's n not UC
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Old 05-17-2012
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i would go with b
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  #10  
Old 05-17-2012
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Default Explanation

A) IL-4, IL-5, IL-6, and IL-10: Ulcerative colitis is mediated by TH2, N.B there is no granuloma present
B) TH1, IL-2, IFN-γ, and TNF: Crohn's disease is mediated by TH1 and presence of granuloma
C) IL-1, IL-6, IL-8, and NO: + PAF + TNF-α + IFN-γ Produce SUPERANTIGEN
D) IL-4, IL-7, IL-9, and IL-15: SCID is X-linked of a complete fuctional T and B cell deficiency, with a defect common of IL-2 receptors
E) IFN-α, IFN-β, and IL-12: Enhance MHC I, NK which are the most important cell for destroying viruses and parasites



KEEP STUDING GUYS!!!!!!!!!!!!!
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