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Old 05-17-2012
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Blood Acute Myeloid Leukemia Diagnosis

In your rotation for oncology as surgery resident in the Johns Hopkins Hospital Baltimore, within the chart of a patient you observe this picture (see the slide); you forget the differentiation between AML/CML and decide to make it by the result of Lab. Which of the following protein(s) should be present in the chart to memorize you to make the diagnosis of acute myeloid leukemia?


A) N-myc and 1p in ganglionar cells
B) Peroxidase positive and t(8;21)
C) PML-RAR alpha gene
D) Proliferation fraction with Ki-67
E) BCR-ABL mRNA fusion
F) Overexpression of HER-2 and p185

Acute Myeloid Leukemia Diagnosis-pic-1.jpg
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Reference: For people who ask me the source all answers are in UW explanation Qbank, and we need to discuss questions if we need success, remember this word: WHY???
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Old 05-17-2012
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ummm D is the only one that kinda makes sense to me.

answer = D?
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C) PML-RAR alpha gene
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Quote:
Originally Posted by Dr.NickRiviera View Post
ummm D is the only one that kinda makes sense to me.

answer = D?
i think ans d is associated w/ non-hodgkin lymphoma (burkitt's)
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Old 05-17-2012
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would go with C.

btw, couldnt really say that - these granulles I see do look like Auer rods I saw on other pics...
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Old 05-17-2012
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RAR translocation t(15:17)
aura rods in histology.

option C
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Old 05-17-2012
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Retinoic acid receptor...
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Quote:
Originally Posted by DocSikorski View Post
these granulles I see do look like Auer rods I saw on other pics...

Here... there are a lot... but definitely Auer Rods. Look for the one with the ôsuper Auer rodô near the center...
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Quote:
Originally Posted by DocSikorski View Post
would go with C.

btw, couldnt really say that - these granulles I see do look like Auer rods I saw on other pics...

Yes, it is man just look at the center. Finally you anderstand one of my questions thank you!!!!!!!!
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Old 05-17-2012
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I go for C...
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Old 05-18-2012
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btw guys, a good example of a board-like picture!

the shiet is in the center! - do not look anywhere else
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Old 05-18-2012
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Default Explanation!!!!

A) N-myc and 1p in ganglionar cells: Neuroblastoma
B) Peroxidase positive and t(8;21): Dx of AML type M2(All of AML type you need to know 2(M2 & M3)
C) PML-RAR alpha gene: AML type M3 in our case(correct answer)
D) Proliferation fraction with Ki-67: Burkitt Lymphoma(UW reference)
E) BCR-ABL mRNA fusion: CML
F) Overexpression of HER-2 and p185: Breast cancer
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