Acetazolamide, Acidosis or Alkalosis? - USMLE Forums
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Old 05-18-2012
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Drug Acetazolamide, Acidosis or Alkalosis?

FA'12 - metabolic alkalosis

Kaplan Qbank QID 200466 - metabolic acidosis

what to believe?
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Old 05-18-2012
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Acetazolamide is a Carbonic Anhydrase inhibitor.
It will increase the secretion of HCO3- and lead to Metabolic Acidosis.
Believe in the concept

Plus its probably an error in FA (since they have oh so many of those )
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Old 05-18-2012
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inhibits CA so less bicarb and H+ being made, means less H+ into urine (increased pH in urine) and less bicarb into the blood (decreased pH in blood).

answer = metabolic acidosis.
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Thnx guys, its logical...
I just used to believe FA
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thats funny they screwed that up in the 2012 fa considering they have a killer mnemonic in the 2011 version

ACETAzolimide causes ACIDOSIS
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Quote:
Originally Posted by DefeatTheBeast View Post
thats funny they screwed that up in the 2012 fa considering they have a killer mnemonic in the 2011 version

ACETAzolimide causes ACIDOSIS
Thao Le forgot the mnemonic he used to remember this mnemonic
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and remember guys, this is one of the strange cases in which you have metabolic acidosis with hypokalemia.
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Quote:
Originally Posted by Dr.NickRiviera View Post
and remember guys, this is one of the strange cases in which you have metabolic acidosis with hypokalemia.
is it the mud piles one?
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Quote:
Originally Posted by DocSikorski View Post
is it the mud piles one?
umm i duno, i dont really remember the whole mud piles thing... and never really understood what it was all about tbh.

i just remember this because my TA in kaplan told us it was a strange finding; in acidosis you almost always have hyperkalemia with it... except in CA inhibitor use.
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Quote:
Originally Posted by Dr.NickRiviera View Post
umm i duno, i dont really remember the whole mud piles thing... and never really understood what it was all about tbh.

i just remember this because my TA in kaplan told us it was a strange finding; in acidosis you almost always have hyperkalemia with it... except in CA inhibitor use.
As far as i remember it doesn't give increased anion gap metabolic acidosis

Diarrhea also gives hypokalemic acidosis
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