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  #1  
Old 05-28-2010
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Immunology Breast Cancer Immunohistochemistry

A 55-year old woman undergoes surgery for a stage II invasive ductal carcinoma. The mass is removed, with the specimen showing negative margins and no lymph node involvement. To determine treatment options, immunohistochemical studies are performed to evaluate expression of receptors for estrogen, progesterone, and HER2-type EGF. Which of the following markers will most likely show immunoreactivity that is limited to the nucleus?

A. Estrogen and HER2 receptors
B. Estrogen and progesterone receptors
C. Estrogen, HER2, and progesterone receptors
D. Estrogen receptor only
E. HER2 receptor only
F. Progesterone receptor only
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  #2  
Old 05-28-2010
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i think its B but not sure
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Old 05-28-2010
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i think is B but not sure too
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Old 05-29-2010
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the ans is b, because both have steroid receptors?
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  #5  
Old 05-29-2010
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Default B

ya correct answer is B. Estrogen and progesterone receptors..as immunogenicity is limited to nucleus only...
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Old 05-29-2010
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Listening Yup2 . .

I think Soo . . It's B
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Old 11-20-2011
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Quote:
Originally Posted by khushboo View Post
A 55-year old woman undergoes surgery for a stage II invasive ductal carcinoma. The mass is removed, with the specimen showing negative margins and no lymph node involvement. To determine treatment options, immunohistochemical studies are performed to evaluate expression of receptors for estrogen, progesterone, and HER2-type EGF. Which of the following markers will most likely show immunoreactivity that is limited to the nucleus?

A. Estrogen and HER2 receptors
B. Estrogen and progesterone receptors
C. Estrogen, HER2, and progesterone receptors
D. Estrogen receptor only
E. HER2 receptor only
F. Progesterone receptor only
can anyone tell me what does immunoreactivity limited to the nucleus mean?
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Old 11-20-2011
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Hey it means that when the pathologist makes an immunostain with special markers for the receptors he is looking for, the stain is just on the nucleus and not on the cell surface. Does this help u?
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Old 11-20-2011
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Originally Posted by Glomerulus View Post
Hey it means that when the pathologist makes an immunostain with special markers for the receptors he is looking for, the stain is just on the nucleus and not on the cell surface. Does this help u?
yea thanks alot

i thought HER-2 affect the nucleus too but it seems to be a tyrosine kinase receptor ..isnt it?
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Old 11-20-2011
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Originally Posted by dr.muhamad View Post
yea thanks alot

i thought HER-2 affect the nucleus too but it seems to be a tyrosine kinase receptor ..isnt it?
Yeah it a tyrosinkinase rec. for Epithelial growth factor I think. So its on the surface
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